Protein Alignment Takl1 and Lrrk

DIOPT Version :10

• Sequence 1: NP_732554.1
• Gene: Takl1 / 318725
• FlyBaseID: FBgn0046689
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Alignment Length: 374
• Identity: 87/374 - (23%)
• Similarity: 149/374 - (39%)
• Gaps: 96/374 - (25%)

  Fly     8 AEVKLSEKFLGAGSGGAVRKAT-----------------------FQNQEIAVKIF--------- 40
            :|..:....||.|:.|.|.||.                       .:.:|.|:..|
  Fly  1793 SECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDR 1857

  Fly    41 DFLEETIKK--NAEREITHLSEIDHENVIRVIG-----------RASNGKKDYLLMEYLEEGSLH 92
            |.|:.:.|.  .|.:|:..|..:.|.|::.::|           .|..|..|.||..|...|:
  Fly  1858 DPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGA-- 1920

  Fly    93 NYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHRDIKPQNMLLYN----QHED------ 147
                  ....:|.:..|   ||.|:|:.|||.  |.|::||:|.:|:|::.    ..||
  Fly  1921 ------HMGPHTFQTLV---LQAARAIEYLHR--RRIIYRDLKSENVLVWELPQPHTEDSPRNLV 1974

  Fly   148 -LKICDFGLATDMS-NNKTDMQGTLRYMAPEAIKH---LKYTAKCDVYSFGIMLWELMTRQLPYS 207
             :||.|:|::...: :......||..:||||.|::   .:||.|.|.:|||:.::|.::.:.|:.
  Fly  1975 HIKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFE 2039

  Fly   208 HLENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCMDINPEKRPSMKEIEKFL------ 266
            ..|      :|.:.|..|.:..:....:..|.....||..|....|.:||:..:|...|
  Fly  2040 GHE------SIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECI 2098

  Fly   267 ----------GEQYESGTDEDFIKPLDEDTVAVVTYHVDSSGSRIMRVD 305
                      .|:...|..:..:...|::...:..: :.|.||||..:|
  Fly  2099 HLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELW-LPSFGSRIDILD 2146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	78/332 (23%)
Lrrk	NP_001262772.1	ANKYR	78..>287	CDD:440430
		ANK repeat	146..177	CDD:293786
		ANK repeat	179..209	CDD:293786
		ANK repeat	361..390	CDD:293786
		Ank_2	364..465	CDD:463710
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR	<544..>768	CDD:443914
		leucine-rich repeat	547..569	CDD:275380
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:404697
		leucine-rich repeat	855..901	CDD:275380
		LRR_4	900..941	CDD:463713
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	993..1211	CDD:476819
		COR	1230..>1393	CDD:406489
		STKc_LRRK	1801..2095	CDD:270902	77/312 (25%)