Protein Alignment Takl1 and MATK

DIOPT Version :10

• Sequence 1: NP_732554.1
• Gene: Takl1 / 318725
• FlyBaseID: FBgn0046689
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_002369.2
• Gene: MATK / 4145
• HGNCID: 6906
• Length: 508
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 85/286 - (29%)
• Similarity: 150/286 - (52%)
• Gaps: 54/286 - (18%)

  Fly    17 LGAGSGGAVRKATFQNQEIAVKIFD-------FLEETIKKNAEREITHLSEIDHENVIRVIGRAS 74
            :|.|..|||.:..:..|::|||...       ||:||         ..::::.|||::|::|...
Human   242 IGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDET---------AVMTKMQHENLVRLLGVIL 297

  Fly    75 NGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHRDIKPQNM 139
            : :..|::||::.:|:|.|:|....:......|.::::|..|:.:.||.|  :.:||||:..:|:
Human   298 H-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLES--KKLVHRDLAARNI 359

  Fly   140 LLYNQHEDL--KICDFGLATDMSNNKTDMQG------TLRYMAPEAIKHLKYTAKCDVYSFGIML 196
            |:   .|||  |:.|||||      |.:.:|      .:::.||||:||.|:|:|.||:|||::|
Human   360 LV---SEDLVAKVSDFGLA------KAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLL 415

  Fly   197 WELMT-RQLPYSHLENPNSQYAIMKAISSGEKL-PMEAVRSDCPEGIKQLMECCMDINPEKRPSM 259
            ||:.: .:.||..:    |...:.:|:..|.:: |.|.    ||..:..||..|.:..|.:||..
Human   416 WEVFSYGRAPYPKM----SLKEVSEAVEKGYRMEPPEG----CPGPVHVLMSSCWEAEPARRPPF 472

  Fly   260 KEIEKFLGEQYE--------SGTDED 277
            :::.:.|..:..        ||.|.|
Human   473 RKLAEKLARELRSAGAPASVSGQDAD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	82/281 (29%)
MATK	NP_002369.2	SH3_CHK	51..109	CDD:212745
		SH3 domain	55..106
		SH2_csk_like	119..216	CDD:198190
		SH2 domain	123..213
		PTKc_Chk	229..482	CDD:270666	81/268 (30%)
		catalytic domain	236..479		80/265 (30%)