DRSC/TRiP Functional Genomics Resources

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Protein Alignment Takl1 and Map3k7

DIOPT Version :10

Sequence 1:NP_732554.1 Gene:Takl1 / 318725 FlyBaseID:FBgn0046689 Length:393 Species:Drosophila melanogaster
Sequence 2:NP_001101390.2 Gene:Map3k7 / 313121 RGDID:1309438 Length:606 Species:Rattus norvegicus


Alignment Length:385 Identity:125/385 - (32%)
Similarity:207/385 - (53%) Gaps:46/385 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KQVDFAEVKLSEKFLGAGSGGAVRKATFQNQEIAVKIFDFLEETIKKNAER-----EITHLSEID 62
            :::|:.|::: |:.:|.|:.|.|.||.::.:::|:|       .|:..:||     |:..||.::
  Rat    29 EEIDYKEIEV-EEVVGRGAFGVVCKAKWRAKDVAIK-------QIESESERKAFIVELRQLSRVN 85

  Fly    63 HENVIRVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWE-YTVEQAVRWALQCAKALAYLHSLD 126
            |.|::::.|...|  ...|:|||.|.|||:|.|:|.:... ||...|:.|.|||::.:|||||:.
  Rat    86 HPNIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQ 148

  Fly   127 -RPIVHRDIKPQNMLLYNQHEDLKICDFGLATDMSNNKTDMQGTLRYMAPEAIKHLKYTAKCDVY 190
             :.::|||:||.|:||......|||||||.|.|:..:.|:.:|:..:||||..:...|:.||||:
  Rat   149 PKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVF 213

  Fly   191 SFGIMLWELMTRQLPYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCMDINPEK 255
            |:||:|||::||:.|:..:..|  .:.||.|:.:|.:.|:   ..:.|:.|:.||..|...:|.:
  Rat   214 SWGIILWEVITRRKPFDEIGGP--AFRIMWAVHNGTRPPL---IKNLPKPIESLMTRCWSKDPSQ 273

  Fly   256 RPSMKEIEKFLGE--QYESGTDEDFIKPL---DEDTVAVVTYHVDSSGSRI--------MRVDFW 307
            ||||:||.|.:..  :|..|.||....|.   ||......|    |:||.:        .:.|..
  Rat   274 RPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSAT----STGSFMDIASTNTSNKSDTN 334

  Fly   308 RHQLPSIRMTFPIVKREAERLGKTVVREMAKAAADGDREVRRAEKDTERETSRAAHNGER 367
            ..|:|:...|.       :||...:::..||..:|..|....|.:.:..|:......|:|
  Rat   335 MEQVPATNDTI-------KRLESKLLKNQAKQQSDSGRLSLGASRGSSVESLPPTSEGKR 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Takl1NP_732554.1 STKc_TAK1 17..274 CDD:270960 98/265 (37%)
Map3k7NP_001101390.2 Interaction with MAPK8IP1. /evidence=ECO:0000250 1..300 104/285 (36%)
STKc_TAK1 42..292 CDD:270960 98/263 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..338 8/40 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..391 8/34 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..492
Blue background indicates that the domain is not in the aligned region.

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