DRSC/TRiP Functional Genomics Resources

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Protein Alignment Takl1 and ABL1

DIOPT Version :10

Sequence 1:NP_732554.1 Gene:Takl1 / 318725 FlyBaseID:FBgn0046689 Length:393 Species:Drosophila melanogaster
Sequence 2:NP_009297.2 Gene:ABL1 / 25 HGNCID:76 Length:1149 Species:Homo sapiens


Alignment Length:432 Identity:100/432 - (23%)
Similarity:188/432 - (43%) Gaps:83/432 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 QVDFAEVKLSEKFLGAGSGGAVRKATFQNQEIAVKIFDFLEETIK-KNAEREITHLSEIDHENVI 67
            :::..::.:..| ||.|..|.|.:..::...:.|.:....|:|:: :...:|...:.||.|.|::
Human   255 EMERTDITMKHK-LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLV 318

  Fly    68 RVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHR 132
            :::|..:.....|::.|::..|:|.:||...::.|......:..|.|.:.|:.||..  :..:||
Human   319 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK--KNFIHR 381

  Fly   133 DIKPQNMLLYNQHEDLKICDFGLATDMSNNK-TDMQGT---LRYMAPEAIKHLKYTAKCDVYSFG 193
            |:..:|.|:...|. :|:.||||:..|:.:. |...|.   :::.|||::.:.|::.|.||::||
Human   382 DLAARNCLVGENHL-VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFG 445

  Fly   194 IMLWELMTRQL-PYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCMDINPEKRP 257
            ::|||:.|..: ||..:: .:..|.:::     :...||.... |||.:.:||..|...||..||
Human   446 VLLWEIATYGMSPYPGID-LSQVYELLE-----KDYRMERPEG-CPEKVYELMRACWQWNPSDRP 503

  Fly   258 SMKEIEKFLGEQY-ESGTDEDFIKPLDEDTV--AVVTYHVDSSGSRIMRVDFWRHQLPSIRMTFP 319
            |..||.:.....: ||...::..|.|.:..|  ||.|.                .|.|.:.....
Human   504 SFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTL----------------LQAPELPTKTR 552

  Fly   320 IVKREAERLGKTVVREMAKAAADGDRE-------------------------------------- 346
            ..:|.||....|.|.||..:...|:.:                                      
Human   553 TSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTN 617

  Fly   347 -----VRRAEKDT----ERETSRAAHNGERETRRAGQDVGRE 379
                 :::.:|..    :|.:|....:|:.|.|.||::.||:
Human   618 LFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRD 659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Takl1NP_732554.1 STKc_TAK1 17..274 CDD:270960 73/263 (28%)
ABL1NP_009297.2 SH3_Abl 84..137 CDD:212784
SH2_ABL 142..235 CDD:198189
PTKc_Abl 254..516 CDD:270645 72/271 (27%)
FABD 1025..1149 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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