DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gba1b and Gba

DIOPT Version :9

Sequence 1:	NP_001097888.1	Gene:	Gba1b / 318721	FlyBaseID:	FBgn0051414	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001121111.1	Gene:	Gba / 684536	RGDID:	1589149	Length:	515	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	183/564 - (32%)
Similarity:	281/564 - (49%)	Gaps:	67/564 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FLTTVIAISAGAPDWQLPCDLRETSHGS-VCVCNSTYCDYLEPPQLTDISQIVVISSSKDGLRFK 74
            ||...|:.:.||.    ||..:...:.| |||||:||||.|:|..|..:.......|::.|.|.:
  Rat     9 FLFQAISWAYGAQ----PCIPKSFGYSSVVCVCNATYCDSLDPLTLPALGTFSRYESTRSGRRME 69

  Fly    75 KTTGDLSKKKPITIDDKQFTDENFKADAIVVDQERAWLQLANIPQSLFINASIKTYRIFVKREQS 139
            .:||.:...:..|                                .|.:.         ::.|:.
  Rat    70 LSTGSIQANRTGT--------------------------------GLLLT---------LQPEEK 93

  Fly   140 FQNVSIFGGAFTGTVSYLLKELPVELQDHVYRSYFHPVGIAYNTIRMSIGGSDFDMEPWAYNELP 204
            ||.|..||||.|...:..:..|....|..:.:|||...||.||.||:.:...||.:..:.|.:.|
  Rat    94 FQKVKGFGGAMTDATALNILALSPPAQKLLLKSYFSSEGIEYNIIRVPMASCDFSIRIYTYADTP 158

  Fly   205 LHDPKLSNFTELDPRDLQKVEQLKR-LKIIGKVDSLKIMGAAWSAPTWMKSNNRWTGFGQLKSE- 267
             :|.:||||:..:.....|:..:.| ||:..:  .:.:..:.|::|||:|:|....|.|.||..
  Rat   159 -NDFQLSNFSLPEEDTKLKIPLIHRALKMSPR--PISLFASPWTSPTWLKTNGAVNGKGSLKGHP 220

  Fly   268 ---YYQTWALYHLKFLELMRSKNMPIWAISTGNEPLNGVIGFFFVHFMSMGWTPWQQAIWLNDNL 329
               |::.||.|.:|||:...:.|:..||::..|||..|:  |....|..:|:|...|..:::.:|
  Rat   221 GDIYHEAWANYFVKFLDAYATHNIKFWAVTAENEPSAGL--FTGYPFQCLGFTAEHQRDFISHDL 283

  Fly   330 GPTIRNSA-ESKVLIFGNDDQRYTYPTWFRKMRSSRNNSLNYLDGLAVHWYWDELI-GPQLIDQA 392
            ||.:.||: :.|:||.  ||||...|.|.:.:.|. ..:..|:.|:|||||.|.|. ....:.:.
  Rat   284 GPALANSSHDVKLLIL--DDQRLLLPRWAQVVLSD-PEAAKYVHGIAVHWYMDFLAPAKATLGET 345

  Fly   393 HTDMPNKLLLNTESCIGDKPWQTHGPELGSWQRGESYMRAYTQDLTHNFNGWLDWNLVLDEQGGP 457
            |...||.:|..:|:|:|.|.|: ....||||.||..|..:...:|.::..||.||||.|:.:|||
  Rat   346 HRLFPNMMLFASEACVGSKFWE-QSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGP 409

  Fly   458 NYVKNFVDAPIIVNATSRSEIYKQPIFYAIGHFSKFLPPDSVRIETRIENQSNPFTQLSVVGFQR 522
            |:|:||||:||||: ..:...||||:||.:||||||:|..|.|:......:    |.|..|...|
  Rat   410 NWVRNFVDSPIIVD-IPKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASEK----TDLETVALIR 469

  Fly   523 PDGSVALIIYNGQNLPVDVTLDDSQRGAIQLRLPPRSWHTVLYK 566
            ||||..:::.|..:..|.:|:.|...|.::...|..|.||.|::
  Rat   470 PDGSAVVVVLNRSSKDVPLTISDPALGFMETISPGYSIHTYLWR 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gba1b	NP_001097888.1	Glyco_hydro_30	28..559	CDD:304972	174/538 (32%)
Gba	NP_001121111.1	Glyco_hydro_30	20..512	CDD:304972	178/550 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352288
Domainoid	1	1.000	232	1.000	Domainoid score	I2327
eggNOG	1	0.900	-	-		E1_COG5520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2770
OMA	1	1.010	-	-		QHG62715
OrthoDB	1	1.010	-	-		D206521at33208
OrthoFinder	1	1.000	-	-		FOG0004266
OrthoInspector	1	1.000	-	-		otm44865
orthoMCL	1	0.900	-	-		OOG6_102859
Panther	1	1.100	-	-	LDO	PTHR11069
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3004
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810