DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gba1b and gba

DIOPT Version :9

Sequence 1:	NP_001097888.1	Gene:	Gba1b / 318721	FlyBaseID:	FBgn0051414	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_687471.3	Gene:	gba / 559072	ZFINID:	ZDB-GENE-100922-270	Length:	518	Species:	Danio rerio

Alignment Length:	565	Identity:	195/565 - (34%)
Similarity:	270/565 - (47%)	Gaps:	66/565 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLGFLTTVIAISAGAPDWQLPCDLRETSHGS-VCVCNSTYCDYLEPPQLTDISQIVVISSSKDGL 71
            |.|.:||..|.|...      |......||| |||||:||||.|....|.|..|.:...|:|.|.
Zfish    10 LAGIITTARADSKDG------CLALNFGHGSVVCVCNATYCDSLGRTVLPDAGQFLSYVSNKAGS 68

  Fly    72 RFKKTTGDLSKKKPITIDDKQFTDENFKADAIVVDQERAWLQLANIPQSLFINASIKTYRIFVKR 136
            |..::.|...|                                         |::....||.:..
Zfish    69 RLMESQGQFQK-----------------------------------------NSTGAALRITLNP 92

  Fly   137 EQSFQNVSIFGGAFTGTVSYLLKELPVELQDHVYRSYFHPVGIAYNTIRMSIGGSDFDMEPWAYN 201
            .|.||::..||||.|...:..:..|....||.:.|.||...||.|..:|:.:...||....:.|.
Zfish    93 SQKFQHIKGFGGAMTDAAAINILSLSSGAQDQLLRQYFSTDGIEYRFVRVPVASCDFSTRLYTYA 157

  Fly   202 ELPLHDPKLSNFTELDPRDL-QKVEQLKRLKIIGKVDSLKIMGAAWSAPTWMKSNNRWTGFGQLK 265
            :.| .|..|.||| |...|: .|:..|:|.:.: ....|.:..:|||||.|:|:|....|.|.||
Zfish   158 DTP-EDYDLQNFT-LAKEDVHMKIPLLQRAQAL-SAQPLYLFASAWSAPAWLKTNGALIGKGSLK 219

  Fly   266 ----SEYYQTWALYHLKFLELMRSKNMPIWAISTGNEPLNGVIGFFFVHFMSMGWTPWQQAIWLN 326
                .:.::|||.|:::|||..|..|:..|.:::||||..|.:..:  .|.::|:||..|..|:.
Zfish   220 GKPGGKEHKTWAQYYIRFLEEYRKYNLSFWGLTSGNEPTAGEMTNY--SFQALGFTPETQRDWIA 282

  Fly   327 DNLGPTIRNSAESKVLIFGNDDQRYTYPTWFRKMRSSRNNSLNYLDGLAVHWYWDELIGPQL-ID 390
            .:|||.:.:|:.||..:...||.|...|.| .|:..|...:..|:.|:.||||:|.|:.|.: :.
Zfish   283 LDLGPALHSSSFSKTQLMILDDNRLMLPHW-AKVVLSDIKAARYVHGIGVHWYFDRLVPPDVTLT 346

  Fly   391 QAHTDMPNKLLLNTESCIGDKPWQTHGPELGSWQRGESYMRAYTQDLTHNFNGWLDWNLVLDEQG 455
            ..|...|:..|..||:|.|..| ...|..||||.|.|.|.....|||.:...||.||||.|::.|
Zfish   347 STHHLYPDYFLFATEACAGWSP-VDRGVRLGSWDRAEDYAHDIIQDLNNYVTGWTDWNLALNQDG 410

  Fly   456 GPNYVKNFVDAPIIVNATSRSEIYKQPIFYAIGHFSKFLPPDSVRIETRIENQSNPFTQLSVVGF 520
            |||:||||||:||||: .|:...||||.||::.||||||..:|.|:......|    |.|.:..|
Zfish   411 GPNWVKNFVDSPIIVD-PSKDIFYKQPTFYSMAHFSKFLWEESQRVGVSFSQQ----TSLEMSAF 470

  Fly   521 QRPDGSVALIIYNGQNLPVDVTLDDSQRGAIQLRLPPRSWHTVLY 565
            .|||.|..|||.|.....|...:.|...|.:....||.|..|:|:
Zfish   471 IRPDASAVLIILNRSEEEVPFEVWDQTVGFLPGSAPPHSILTLLW 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gba1b	NP_001097888.1	Glyco_hydro_30	28..559	CDD:304972	186/537 (35%)
gba	XP_687471.3	Glyco_hydro_30	34..515	CDD:304972	185/533 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594222
Domainoid	1	1.000	245	1.000	Domainoid score	I2141
eggNOG	1	0.900	-	-		E1_COG5520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2710
OMA	1	1.010	-	-		QHG62715
OrthoDB	1	1.010	-	-		D206521at33208
OrthoFinder	1	1.000	-	-		FOG0004266
OrthoInspector	1	1.000	-	-		otm25617
orthoMCL	1	0.900	-	-		OOG6_102859
Panther	1	1.100	-	-	LDO	PTHR11069
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3226
SonicParanoid	1	1.000	-	-		X3004
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800