Protein Alignment Gba1b and GBA

DIOPT Version :9

• Sequence 1: NP_001097888.1
• Gene: Gba1b / 318721
• FlyBaseID: FBgn0051414
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_000148.2
• Gene: GBA / 2629
• HGNCID: 4177
• Length: 536
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 184/569 - (32%)
• Similarity: 282/569 - (49%)
• Gaps: 65/569 - (11%)

  Fly     8 LLGFLTTVIAISAGAPDW---QLPCDLRETSHGS-VCVCNSTYCDYLEPPQLTDISQIVVISSSK 68
            :.|.||.::.:.  |..|   ..||..:...:.| |||||:||||..:||....:.......|::
Human    21 MAGSLTGLLLLQ--AVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTR 83

  Fly    69 DGLRFKKTTGDLSKKKPITIDDKQFTDENFKADAIVVDQERAWLQLANIPQSLFINASIKTYRIF 133
            .|.|.:.:.|      ||        ..|.....::                           :.
Human    84 SGRRMELSMG------PI--------QANHTGTGLL---------------------------LT 107

  Fly   134 VKREQSFQNVSIFGGAFTGTVSYLLKELPVELQDHVYRSYFHPVGIAYNTIRMSIGGSDFDMEPW 198
            ::.||.||.|..||||.|...:..:..|....|:.:.:|||...||.||.||:.:...||.:..:
Human   108 LQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTY 172

  Fly   199 AYNELPLHDPKLSNFTELDPRDLQKVEQLKR-LKIIGKVDSLKIMGAAWSAPTWMKSNNRWTGFG 262
            .|.:.| .|.:|.||:..:.....|:..:.| |::..:..||  :.:.|::|||:|:|....|.|
Human   173 TYADTP-DDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSL--LASPWTSPTWLKTNGAVNGKG 234

  Fly   263 QLKSE----YYQTWALYHLKFLELMRSKNMPIWAISTGNEPLNGVIGFFFVHFMSMGWTPWQQAI 323
            .||.:    |:||||.|.:|||:......:..||::..|||..|::..:  .|..:|:||..|..
Human   235 SLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGY--PFQCLGFTPEHQRD 297

  Fly   324 WLNDNLGPTIRNSAESKVLIFGNDDQRYTYPTWFRKMRSSRNNSLNYLDGLAVHWYWDELI-GPQ 387
            ::..:||||:.||....|.:...||||...|.| .|:..:...:..|:.|:|||||.|.|. ...
Human   298 FIARDLGPTLANSTHHNVRLLMLDDQRLLLPHW-AKVVLTDPEAAKYVHGIAVHWYLDFLAPAKA 361

  Fly   388 LIDQAHTDMPNKLLLNTESCIGDKPWQTHGPELGSWQRGESYMRAYTQDLTHNFNGWLDWNLVLD 452
            .:.:.|...||.:|..:|:|:|.|.|: ....||||.||..|..:...:|.::..||.||||.|:
Human   362 TLGETHRLFPNTMLFASEACVGSKFWE-QSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALN 425

  Fly   453 EQGGPNYVKNFVDAPIIVNATSRSEIYKQPIFYAIGHFSKFLPPDSVRIETRIENQSNPFTQLSV 517
            .:||||:|:||||:||||:.| :...||||:||.:||||||:|..|.|:.. :.:|.|   .|..
Human   426 PEGGPNWVRNFVDSPIIVDIT-KDTFYKQPMFYHLGHFSKFIPEGSQRVGL-VASQKN---DLDA 485

  Fly   518 VGFQRPDGSVALIIYNGQNLPVDVTLDDSQRGAIQLRLPPRSWHTVLYK 566
            |....||||..:::.|..:..|.:|:.|...|.::...|..|.||.|::
Human   486 VALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWR 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gba1b	NP_001097888.1	Glyco_hydro_30	28..559	CDD:304972	175/537 (33%)
GBA	NP_000148.2	Glyco_hydro_30	117..466	CDD:307945	132/356 (37%)
		Glyco_hydro_30C	469..531	CDD:319207	18/65 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158304
Domainoid	1	1.000	240	1.000	Domainoid score	I2262
eggNOG	1	0.900	-	-		E1_COG5520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2758
Isobase	1	0.950	-	0	Normalized mean entropy	S4252
OMA	1	1.010	-	-		QHG62715
OrthoDB	1	1.010	-	-		D206521at33208
OrthoFinder	1	1.000	-	-		FOG0004266
OrthoInspector	1	1.000	-	-		otm40726
orthoMCL	1	0.900	-	-		OOG6_102859
Panther	1	1.100	-	-	LDO	PTHR11069
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3004
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720