Protein Alignment Gba1b and gba-4

DIOPT Version :9

• Sequence 1: NP_001097888.1
• Gene: Gba1b / 318721
• FlyBaseID: FBgn0051414
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_500785.1
• Gene: gba-4 / 177314
• WormBaseID: WBGene00021160
• Length: 519
• Species: Caenorhabditis elegans
• Alignment Length: 564
• Identity: 183/564 - (32%)
• Similarity: 270/564 - (47%)
• Gaps: 93/564 - (16%)

  Fly    27 LPCDLRETSHGSVCVCNSTYCDYLEPPQLTDISQIVVISSSKDGLR-----FKKTTGDLSKKKPI 86
            |||...:..:|.||.||:||||.:||.......:.||.::|::|.|     .|.||...:|.|
 Worm    25 LPCSEVKKEYGIVCRCNATYCDTIEPLGTVTSGKAVVYTTSRNGKRMNRSELKHTTSSTAKTK-- 87

  Fly    87 TIDDKQFTDENFKADAIVVDQERAWLQLANIPQSLFINASIKTYRIFVKREQSFQNVSIFGGAFT 151
                                                         ::|...||||.|..||.|||
 Worm    88 ---------------------------------------------VYVNTTQSFQPVMGFGAAFT 107

  Fly   152 GTVSYLLKELPVELQDHVYRSYFHPVGIAYNTIRMSIGGSDFDMEPWAYNELPLHDPKLSNFTEL 216
            ......:|.||..:||.:.:.||...|:.|...|:.:..:||....::|:::.. |..|.|| .|
 Worm   108 DAAGINMKMLPQTMQDQIIQQYFSDDGLGYVFGRVPMASTDFSTHEYSYDDVKF-DFDLKNF-NL 170

  Fly   217 DPRDLQ-KVEQLKRLKII--GKVDSLKIMGAAWSAPTWMKSNNRWTGFGQL----KSEYYQTWAL 274
            ...||| |:..:|:....  ||   ||:....||:|.|||::.|..|.|:|    ..:||||||.
 Worm   171 TVEDLQYKIPFIKKAMTASGGK---LKLFATPWSSPGWMKTSGRMVGAGELLGDQNGKYYQTWAQ 232

  Fly   275 YHLKFLELMRSKNMPIWAISTGNEPLNGVIGFFFVHFMSMGWTPWQ--------QAIWLNDNLGP 331
            |.:||.|...::.:..|:::..|||..|:...         | .||        :..::...|||
 Worm   233 YFVKFFEAYHAQGIDFWSLTPQNEPTTGIDPL---------W-KWQTLFFDASMERNFIKKLLGP 287

  Fly   332 TIRNSAESKVL-IFGNDDQRYTYPTWFRKMRSSRNNSLNYLDGLAVHWYWDELIGPQLIDQAHTD 395
            .:.:|..:|.| |..|||||...|.|...:.:. ..:..|:.|:|:|||.|.:....::.:.|..
 Worm   288 ALASSPVTKNLKIMINDDQRINLPHWPNVILTD-PTAAQYVHGIAIHWYEDFIDPATVLTETHEK 351

  Fly   396 MPNKLLLNTESCIGDKPWQTHGPELGSWQRGESYMRAYTQDLTHNFNGWLDWNLVLDEQGGPNYV 460
            .|:..||.||:|.|..|  ..||:||||.|.|.|.....:|:.:...||:|||.:||.|||||..
 Worm   352 FPDYFLLATEACAGYFP--ADGPKLGSWSRAEQYANDLIKDMGNWVGGWVDWNYILDLQGGPNLA 414

  Fly   461 KNFVDAPIIVNATSRSEIYKQPIFYAIGHFSKFLPPDSVRIETRIENQSNPFTQLSVVGFQRPDG 525
            |||||:.||||||:: |.|||||::.:..||||:.|.::|:...|..:|.....||   |...||
 Worm   415 KNFVDSTIIVNATAQ-EYYKQPIWHVMAQFSKFVKPGAIRVGINIIEKSVDVEGLS---FLNQDG 475

  Fly   526 SVALIIYN-GQNLPVDVTLDDSQRGAI--QLRLPPRSWHTVLYK 566
            :..:::.| .:.|..||.:.|.....:  .|.:.|.|..|::||
 Worm   476 TKTVVLLNKNEVLSFDVAISDVSAPNVIYDLTIQPNSLITIVYK 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gba1b	NP_001097888.1	Glyco_hydro_30	28..559	CDD:304972	178/554 (32%)
gba-4	NP_500785.1	Glyco_hydro_30	26..516	CDD:304972	179/558 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166000
Domainoid	1	1.000	225	1.000	Domainoid score	I1442
eggNOG	1	0.900	-	-		E1_COG5520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I1794
Isobase	1	0.950	-	0	Normalized mean entropy	S4252
OMA	1	1.010	-	-		QHG62715
OrthoDB	1	1.010	-	-		D206521at33208
OrthoFinder	1	1.000	-	-		FOG0004266
OrthoInspector	1	1.000	-	-		mtm4803
orthoMCL	1	0.900	-	-		OOG6_102859
Panther	1	1.100	-	-	O	PTHR11069
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3226
SonicParanoid	1	1.000	-	-		X3004
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750