DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox4 and Qsox3

DIOPT Version :9

Sequence 1:	NP_732891.1	Gene:	Qsox4 / 318720	FlyBaseID:	FBgn0051413	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_650997.1	Gene:	Qsox3 / 42582	FlyBaseID:	FBgn0038918	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	186/561 - (33%)
Similarity:	294/561 - (52%)	Gaps:	57/561 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLCVLILSAGRGEL--------LFNADDNVVQLDFASFESGLSEPTSGKLVQFFNGFCEESQNFI 69
            ::.:||:..|..:.        |::.:||:..:..||.:..|:||..||||||.|.:|...:.|.
  Fly    13 IILILIVQEGHSKQRCLDEEPPLYSKEDNIHVVVGASLKKILAEPAMGKLVQFLNSYCGNCRRFA 77

  Fly    70 PAFKNLSRKLYKWHRLLKVHVLDCGKDENDMICSIYSIRKTPTLRYFPPSYKLAPDNLGTEITHR 134
            ..|:.::..|.||:|:|:::.:||.:.||..:|..:.|..|||:||:|..::.....:||:|...
  Fly    78 HTFRKMAVDLQKWNRVLRIYAVDCARLENVKLCRDFRITLTPTIRYYPSKFQRIRHGIGTDIETT 142

  Fly   135 NPKEIQSKLALNLQKLDYFKMFKRQDNVAHIFQTHKDIEYVAFVFQMCLDHFLPHLETGNSMEEK 199
            .|.||..:|..:|.:.||    .....|..||..                     :|.||.:.:.
  Fly   143 IPSEIADQLIESLSENDY----SESKGVKPIFDP---------------------IEPGNKLNDI 182

  Fly   200 YASQGDCNEDNPIVSLI-------GRNTLLELLPYRKVVVRIFDNHDVYNKFGISPVPNLVVLVN 257
            |.     ..||.:..::       |..|:|.:|||..|.|||..:.:::.:||:.|...:|.|:|
  Fly   183 YE-----QFDNKVTYILLVHPVDMGIETILNMLPYPDVGVRIIKDAEMFAQFGLKPCKQMVALLN 242

  Fly   258 KAGKLLFLTPEMDSSKAYVAAIKQFLIFVDLKPQKPLPKTPPAN----ISEALRYEIFEQHKHHP 318
            ::||...:.|...||.|||.::...|   .......:|..|||.    :||.....|.:...:..
  Fly   243 RSGKAQLIKPAGKSSSAYVESVAGLL---HQNGHTSMPTLPPAEPEYILSEGYDAFIVDYVLNST 304

  Fly   319 SRIYRADLERAIDQILNVKFPGTTHFAGAKIVVLRNFVKLIYNSSPLKPEAREKLANLYYSLHVK 383
            ..:::||||:||.|.|:|:.|.|...:|.|...||:.::|....:.|..:.|..|.:|...|...
  Fly   305 KVLFQADLEQAIYQFLHVEIPKTAFISGFKFKALRHIIRLFRRFNVLNRDGRRMLNSLVNHLFEV 369

  Fly   384 KQLSGVGFKNLL--LKSVKDYVFDGKQYVGCIASRPSLRGFNCSLWVLFHYLSVESKKLK---PK 443
            .:::|..|::::  |::..|.:|..:|||||:.|.|..|.|:||||.||||.:|.:.::|   |.
  Fly   370 TEITGEEFRDVVDDLQTRLDPIFAEQQYVGCLGSTPHTRRFSCSLWTLFHYFTVLAAQMKVYPPS 434

  Fly   444 SVLLVFLGYVRFFMNCKECDMKISEFKKLRPIANVTNDDEQILWLWEAHNYVNKQLAGDSTEDPK 508
            ||.:...|..:||.:||:..|...:..|...||.|...||:|||||||||.||::||||::.||:
  Fly   435 SVTIGLYGLAKFFYDCKDGSMYFVKLAKRMNIAKVRTHDEEILWLWEAHNEVNEKLAGDASGDPR 499

  Fly   509 FPKIQFPSERDCPKCRNNATEWRTEEVLHYLKGIYTLKNLS 549
            |||:|||..:.||.|..::.|:..:|||.|||.:|.|..||
  Fly   500 FPKVQFPERKHCPDCYTHSGEFDRDEVLKYLKRVYNLSYLS 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox4	NP_732891.1	PDI_a_QSOX	32..145	CDD:239290	41/112 (37%)
Qsox4	NP_732891.1	Evr1_Alr	425..512	CDD:282612	43/89 (48%)
Qsox3	NP_650997.1	PDI_a_QSOX	40..153	CDD:239290	41/112 (37%)
Qsox3	NP_650997.1	Evr1_Alr	413..503	CDD:282612	43/89 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469394
Domainoid	1	1.000	65	1.000	Domainoid score	I3612
eggNOG	1	0.900	-	-		E1_KOG1731
Homologene	1	1.000	-	-		H65608
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1610
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm1146
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	P	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
	12	11.800