DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox4 and Qsox1

DIOPT Version :9

Sequence 1:	NP_732891.1	Gene:	Qsox4 / 318720	FlyBaseID:	FBgn0051413	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001286383.1	Gene:	Qsox1 / 36464	FlyBaseID:	FBgn0033814	Length:	637	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	162/553 - (29%)
Similarity:	273/553 - (49%)	Gaps:	52/553 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LFNADDNVVQLDFASFESGLSEPTSGKLVQFFNGFCEESQNFIPAFKNLSRKLYKWHRLLKVHVL 91
            |::..|.|::|...:|.:.:.:...|.||:|:|.:|...:.|.|.:|:::..|..|..:|.|..:
  Fly    44 LYDDGDKVIRLSVDNFNATVLDQNRGALVEFYNTYCGHCRRFAPTYKSVAEHLLPWSEVLIVAAI 108

  Fly    92 DCGKDENDMICSIYSIRKTPTLRYFPPSYKLAPDNLGTEITHRNPKEIQSKLALNLQKLDYFKMF 156
            ||..:||:.||..|.:...|||||..|.::..|.:.|..:..::..||:..||
  Fly   109 DCAAEENNGICRNYEVMGYPTLRYLGPGFQPGPQHYGQSLHTQDKNEIREILA------------ 161

  Fly   157 KRQDNVA--HIFQTHKDIEYVAFVFQMCLDHFLPHLETGNSMEEKYASQGD--CNEDNPIVSLIG 217
               ..||  ::..:|.:..:..|       |:|...::.:|:.|..:|..:  .....|..:.:|
  Fly   162 ---GMVAAENLTSSHNNSYWPNF-------HYLTENDSASSLFEGLSSATEYVAVVHEPENTTLG 216

  Fly   218 RNTLLELLPYRKVVVRIFDNHDVYNKFGISPVPNLVVLVNKAGKLLFLTPEMDSSKAYVAAIKQF 282
            ....|.:..:..|.||...:..|..||.|.|....:.||::.|::....||..:.::|...:...
  Fly   217 VEVALFMTQWPAVRVRRVIDPAVAAKFKIDPTNLPLSLVDRKGEITAYAPESTNGESYAKKLWDV 281

  Fly   283 LIFVDLKPQKPL----PKTPPANISEALRYEIFEQH--KHHPSRIYRADLERAIDQILNVKFPGT 341
            |...::.| :|:    |...||:..:.....|.|.|  ||.   :|:||||:||..:|:.:....
  Fly   282 LGKKNITP-RPVKVHQPSATPASKIKGQNELIDEVHRNKHF---VYQADLEQAIRTVLHNEVSKV 342

  Fly   342 THFAGAKIVVLRNFVKLIYNSSPLKPEAREKLANL--YYSLHVKKQLSGVGFKNLL--LKSVKDY 402
            ...:|.|::.|:.|:.::...:||.....:.::.|  |......::|:|..|:..|  |::....
  Fly   343 GEISGEKLLALQRFLAVLQRYNPLGANGHQLVSKLKDYVVQFNDQRLTGSQFEEELKRLEAHLSP 407

  Fly   403 VFDGKQYVGCIASRPSLRGFNCSLWVLFHYLSVES----KKLKPKSVLLVFLGYVRFFMNCKECD 463
            |:....:|||:.|.|.||||:||||.|||:::|::    :...|..||....||::.|..|.||.
  Fly   408 VYSSNHFVGCVGSSPRLRGFSCSLWTLFHFMTVQAANNEETQDPLEVLQAMHGYIKNFFGCTECS 472

  Fly   464 MKISEFKKLRPIANVTNDDEQILWLWEAHNYVNKQLAGDSTEDPKFPKIQFPSERDCPKC----- 523
            .........|.|.:|.|.:|.:||||.|||.||::||||:||||:|||.|||:...|.:|
  Fly   473 EHFQAMASRRKIWSVPNKEEAVLWLWAAHNEVNQRLAGDATEDPEFPKKQFPAPESCNECYRTPV 537

  Fly   524 ---RNNATEWRTEEVLHYLKGIYTLKNLSWFGM 553
               .|...||..:.||.:||.|:..:.:|.:|:
  Fly   538 SKSENLEIEWNKDAVLGFLKNIHNPQFVSRYGV 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox4	NP_732891.1	PDI_a_QSOX	32..145	CDD:239290	35/112 (31%)
Qsox4	NP_732891.1	Evr1_Alr	425..512	CDD:282612	40/90 (44%)
Qsox1	NP_001286383.1	PDI_a_QSOX	49..162	CDD:239290	36/127 (28%)
Qsox1	NP_001286383.1	Evr1_Alr	430..521	CDD:282612	40/90 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469396
Domainoid	1	1.000	65	1.000	Domainoid score	I3612
eggNOG	1	0.900	-	-		E1_KOG1731
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1610
Isobase	1	0.950	-	0	Normalized mean entropy	S4773
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm1146
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	P	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
	12	11.750