DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Qsox4 and qsox1

DIOPT Version :9

Sequence 1:	NP_732891.1	Gene:	Qsox4 / 318720	FlyBaseID:	FBgn0051413	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001121836.1	Gene:	qsox1 / 100004382	ZFINID:	ZDB-GENE-030131-7019	Length:	778	Species:	Danio rerio

Alignment Length:	578	Identity:	147/578 - (25%)
Similarity:	266/578 - (46%)	Gaps:	98/578 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSAF--SLLLCVLILSAGRGELLFNADDNVVQLDFASFESGLSEPTSGKLVQFFNGFCEESQNFI 69
            |.||  .:.||.::..||    |:.|.|.|:.|...:.:|.|...|:..||:|:..:|.....|.
Zfish    25 LCAFITCVSLCPVLCEAG----LYTASDQVIVLTPENVDSTLFNNTAALLVEFYATWCGHCIAFS 85

  Fly    70 PAFKNLSRKLYKWHRLLKVHVLDCGKDENDMICSIYSIRKTPTLRYFPPSYKLAPDNLGTEITHR 134
            |.:|:|:|.:.:|...:.:..:||..:.|..:|:.:.|...|::::|.....:....|......|
Zfish    86 PVWKSLARDIKEWKPAVDLAAIDCANESNRKVCTNFGITGYPSIKFFHAYSSIGSRGLEVRGFSR 150

  Fly   135 NPKEIQSKLALNLQ-----------KLDYFKMFKRQDNVAHIFQTHKDIEYVAFVFQMCLDHFLP 188
            :.:.::..:..||:           .|:    ...:..|.|.|..: :::|:|.||
Zfish   151 DVRGLRQYIIENLELHTEAWPPACPPLE----TASEAEVHHFFPAN-NVKYLALVF--------- 201

  Fly   189 HLETGNSMEEKYASQGDCNEDNPIVSLIGRNTLLELLPYRKVVV-RIFDNH-DVYNKFGISPVPN 251
                    |.|             .|.:||...|:||.|..:.| |:.|.. ::.::||::..|:
Zfish   202 --------ENK-------------KSYVGREVTLDLLQYENIAVRRVLDTETNLVSRFGVTEFPS 245

  Fly   252 LVVLVNKAGKLLFLTPEMDSSKAYVAAIKQFLIFVDLKPQKPLP--------KTPPANISEALRY 308
             ..|.:.:|.:..|....::...|..|:::            ||        :||   |:|.::.
Zfish   246 -CYLYDSSGNITRLKVLKEARTFYSYALQR------------LPGVVRTGKHQTP---ITELIKN 294

  Fly   309 EIFEQHK-HHPSRIYRADLERAIDQILNVKFPGTTHFAGAKIVVLRNFVKLIYNSSPLKPEAREK 372
            ...::.: .:.||:|.:|||.|:...|.|:....|..:|..::.|:.::.::....|.:|..:..
Zfish   295 STLQEWRPFNKSRVYMSDLESALHYSLRVELSSHTSISGDDLIALKKYINVLAKYFPGRPSVKSA 359

  Fly   373 LANLYYSLHVKK--QLSGVGFKNLL--LKSVKDYVF-DGKQYVGCIASRPSLRGFNCSLWVLFHY 432
            |..:...|..:|  ::....|:::|  :....|.|. :|.|:|||..|:...||:.|::|.|||.
Zfish   360 LQAVDSWLQSQKGTEIKYSDFRDVLDNVVQTSDAVLPEGVQWVGCQGSQARYRGYPCAVWTLFHV 424

  Fly   433 LSVESKKL-----KPKSVLLVFLGYVRFFMNCKECDMKISEFKKL--RPIANVTNDDEQILWLWE 490
            |:|::|::     :|:.|||...|||..|..|:.|   .:.|:.:  ..:..|.:....::|||.
Zfish   425 LTVQAKEMGSTVSEPQEVLLAMRGYVSSFFGCRPC---ATHFEAMAAESMDQVNSLSGAVIWLWS 486

  Fly   491 AHNYVNKQLAGDSTEDPKFPKIQFPSERDCPKCRN----NATEWRTEEVLHYLKGIYT 544
            .||.||.:||||.:|||.|||||:||...||.|..    ....|..:||..:|:..::
Zfish   487 RHNRVNNRLAGDLSEDPHFPKIQWPSPELCPSCHGVTIIGDHNWIKDEVPQFLQNYFS 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox4	NP_732891.1	PDI_a_QSOX	32..145	CDD:239290	25/112 (22%)
Qsox4	NP_732891.1	Evr1_Alr	425..512	CDD:282612	35/93 (38%)
qsox1	NP_001121836.1	PDI_a_QSOX	48..161	CDD:239290	25/112 (22%)
qsox1	NP_001121836.1	Evr1_Alr	417..508	CDD:282612	35/93 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579252
Domainoid	1	1.000	45	1.000	Domainoid score	I12168
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.720