DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsor1 and MEK1

DIOPT Version :9

Sequence 1:	NP_511098.1	Gene:	Dsor1 / 31872	FlyBaseID:	FBgn0010269	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_194337.1	Gene:	MEK1 / 828713	AraportID:	AT4G26070	Length:	354	Species:	Arabidopsis thaliana

Alignment Length:	388	Identity:	141/388 - (36%)
Similarity:	204/388 - (52%)	Gaps:	57/388 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVLPPVNTEATVAAATVAPTPPFKTPSGT--DTHSLLGKPKTSIDALTE-----TLEGLDMGDTE 65
            :.|||:  |.:::        .|.|.|||  |....:.|......:|:|     .:|.||
plant    11 ICLPPL--EQSIS--------KFLTQSGTFKDGDLRVNKDGIQTVSLSEPGAPPPIEPLD----- 60

  Fly    66 RKRIKMFLSQKEKIGELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQI 130
                          .:||..|||.:..:|.|:.|.|..|:|..|....|.|:|.|..:.:..:.|
plant    61 --------------NQLSLADLEVIKVIGKGSSGNVQLVKHKLTQQFFALKVIQLNTEESTCRAI 111

  Fly   131 LRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKG 195
            .:||::......|::|..|.:||.:|.:||.:|:||||||..:||:.|::||::|..|...||:|
plant   112 SQELRINLSSQCPYLVSCYQSFYHNGLVSIILEFMDGGSLADLLKKVGKVPENMLSAICKRVLRG 176

  Fly   196 LSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTH 258
            |.|:.....|||||:||||:|:|..||:||.|||||..|  ..|:|||||||..||||||:.|:.
plant   177 LCYIHHERRIIHRDLKPSNLLINHRGEVKITDFGVSKILTSTSSLANSFVGTYPYMSPERISGSL 241

  Fly   259 YSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNE 323
            ||.:||||||||.|:|.|.|.:|..||.            .:.|.       .:::||:|.||..
plant   242 YSNKSDIWSLGLVLLECATGKFPYTPPE------------HKKGW-------SSVYELVDAIVEN 287

  Fly   324 PPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVDISGWVCKTMDLPP 386
            |||.....:||.||..|:..|::|.|.:|...|.||.|.:::..|..:.::|.:......|.|
plant   288 PPPCAPSNLFSPEFCSFISQCVQKDPRDRKSAKELLEHKFVKMFEDSDTNLSAYFTDAGSLIP 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsor1	NP_511098.1	PKc_MEK	85..382	CDD:132946	121/298 (41%)
Dsor1	NP_511098.1	S_TKc	88..364	CDD:214567	117/277 (42%)
MEK1	NP_194337.1	PKc_MAPKK_plant_like	66..332	CDD:132954	119/284 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	225	1.000	Domainoid score	I683
eggNOG	1	0.900	-	-		E1_KOG0581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2063
Inparanoid	1	1.050	235	1.000	Inparanoid score	I1115
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	1	1.000	-	-		FOG0000715
OrthoInspector	1	1.000	-	-		otm2995
orthoMCL	1	0.900	-	-		OOG6_100914
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X438
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.730