DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsor1 and Map2k2

DIOPT Version :9

Sequence 1:	NP_511098.1	Gene:	Dsor1 / 31872	FlyBaseID:	FBgn0010269	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	XP_006241049.1	Gene:	Map2k2 / 58960	RGDID:	61888	Length:	401	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	246/405 - (60%)
Similarity:	300/405 - (74%)	Gaps:	36/405 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLPPVNTEATVAAATVAPTPPFKTPSGTDTHSLLGKPKTSIDALTETLEGLDMGDTERKRIKMFL 73
            |||.:....|:|.   .|:|   |..|.....|:.        |.:.||.||:.:.:|||::.||
  Rat     8 VLPALTINPTIAE---GPSP---TSEGASEAHLVD--------LQKKLEELDLDEQQRKRLEAFL 58

  Fly    74 SQKEKIGELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLH 138
            :||.|:|||.|:|.|::.|||:||||||.|.||..:.|||||||||||:|||::.||:|||:|||
  Rat    59 TQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLH 123

  Fly   139 ECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNH 203
            |||.|:|||||||||||||||||||:|||||||.:||.|.||||.|||::::|||:||:|||:.|
  Rat   124 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKH 188

  Fly   204 AIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSL 268
            .|:|||||||||||||.||||:||||||||||||||||||||||||||||||||||||||||||:
  Rat   189 QIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSM 253

  Fly   269 GLSLVEMAIGMYPIPPPNTATLESIF-------ADNAEESGQPTDEP--------------RAMA 312
            ||||||:|||.||||||:...||:.|       ||....|..|...|              .|||
  Rat   254 GLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMA 318

  Fly   313 IFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVDISGW 377
            ||||||||||||||||...:||::|::||:.||.|.|.||||||.|.:|.:|:::|.|:||.:||
  Rat   319 IFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLTNHAFIKRSEGEDVDFAGW 383

  Fly   378 VCKTMDL-PPSTPKR 391
            :|:|:.| .||||.|
  Rat   384 LCRTLRLKQPSTPTR 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsor1	NP_511098.1	PKc_MEK	85..382	CDD:132946	212/317 (67%)
Dsor1	NP_511098.1	S_TKc	88..364	CDD:214567	203/296 (69%)
Map2k2	XP_006241049.1	PKc_MEK	70..388	CDD:132946	212/317 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343074
Domainoid	1	1.000	413	1.000	Domainoid score	I652
eggNOG	1	0.900	-	-		E1_KOG0581
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	486	1.000	Inparanoid score	I1382
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566457at33208
OrthoFinder	1	1.000	-	-		FOG0000715
OrthoInspector	1	1.000	-	-		otm44591
orthoMCL	1	0.900	-	-		OOG6_100914
Panther	1	1.100	-	-	LDO	PTHR48013
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X438
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760