DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsor1 and map2k2a

DIOPT Version :9

Sequence 1:	NP_511098.1	Gene:	Dsor1 / 31872	FlyBaseID:	FBgn0010269	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001032468.2	Gene:	map2k2a / 563181	ZFINID:	ZDB-GENE-041027-1	Length:	397	Species:	Danio rerio

Alignment Length:	386	Identity:	246/386 - (63%)
Similarity:	300/386 - (77%)	Gaps:	22/386 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PTPPFKTPSGT-DTHSLLGKPKTSIDALTETLEGLDMGDTERKRIKMFLSQKEKIGELSDEDLEK 89
            |.|...||:|. .:.::....:.:::||...|..||:.:.:|||::.||:||.::|||.|||.|.
Zfish     7 PVPLIITPTGEGQSTNIDAAAEANLEALQRKLGELDLDEQQRKRLEAFLTQKAQVGELKDEDFEP 71

  Fly    90 LGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYS 154
            :.|||:||||||.||||..:.|:|||||||||:||||:.||:|||:||||||.|:||||||||||
Zfish    72 ICELGAGNGGVVHKVRHKPSRLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYS 136

  Fly   155 DGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNS 219
            |||||||||:|||||||.:||.|.||||.|||::::|||:||:|||:.|.|:|||||||||||||
Zfish   137 DGEISICMEHMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNS 201

  Fly   220 SGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPP 284
            .||||:|||||||||||||||||||||||||||||||||||||||:||:||||||:|||.|||||
Zfish   202 RGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGRYPIPP 266

  Fly   285 PNTATLESIF------ADNAE--------------ESGQPTDEPRAMAIFELLDYIVNEPPPKLE 329
            |:...||:||      |..||              .||...|...|||||||||||||||||||.
Zfish   267 PDAKELEAIFGRPVLDAGGAEGHSMSPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLP 331

  Fly   330 HKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVDISGWVCKTMDL-PPSTP 389
            |.:|:|:|::||..||.|.|.:|||||.|:.|.:|::||:||||.:||:||||.| .||||
Zfish   332 HGVFTTDFEEFVTKCLIKNPADRADLKMLMGHTFIKRAEVEEVDFAGWLCKTMGLHQPSTP 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsor1	NP_511098.1	PKc_MEK	85..382	CDD:132946	218/316 (69%)
Dsor1	NP_511098.1	S_TKc	88..364	CDD:214567	205/295 (69%)
map2k2a	NP_001032468.2	PKc_MEK2	63..393	CDD:132980	228/330 (69%)
map2k2a	NP_001032468.2	S_TKc	69..366	CDD:214567	205/296 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583268
Domainoid	1	1.000	409	1.000	Domainoid score	I663
eggNOG	1	0.900	-	-		E1_KOG0581
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1389
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566457at33208
OrthoFinder	1	1.000	-	-		FOG0000715
OrthoInspector	1	1.000	-	-		otm26205
orthoMCL	1	0.900	-	-		OOG6_100914
Panther	1	1.100	-	-	LDO	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	1	1.000	-	-		X438
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790