DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dsor1 and MAP2K5

DIOPT Version :9

Sequence 1:	NP_511098.1	Gene:	Dsor1 / 31872	FlyBaseID:	FBgn0010269	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_660143.1	Gene:	MAP2K5 / 5607	HGNCID:	6845	Length:	448	Species:	Homo sapiens

Alignment Length:	382	Identity:	145/382 - (37%)
Similarity:	223/382 - (58%)	Gaps:	47/382 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EATVAAATVAPTPPF----KTPSGTDTHSL-----LGKPKTSIDALTETL--EGLDMGDTERKRI 69
            |..|....:.|...|    |.|...:.|.|     .|..:.|..|::::|  ..|.....|.|:|
Human    91 EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKI 155

  Fly    70 KMFLSQKEKIGELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILREL 134
               |:.    |:::::|:.....||.||||.|.|..|..:..|:|.|:|.|::...::|||:.||
Human   156 ---LAN----GQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSEL 213

  Fly   135 KVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYL 199
            ::|::|:..:|:||||||:.:..||||.|:|||||||:..|    :||.:||||.:||:|||:||
Human   214 EILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----MPEHVLGRIAVAVVKGLTYL 274

  Fly   200 RDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSD 264
            . :..|:||||||||:|||:.|::|:||||||.||::|:|.::|||.:||:|||:.|..|.:.||
Human   275 W-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSD 338

  Fly   265 IWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPKLE 329
            :||||:|.:|:|:|.:|.|                   |......::...:||..||:|..|.|.
Human   339 VWSLGISFMELALGRFPYP-------------------QIQKNQGSLMPLQLLQCIVDEDSPVLP 384

  Fly   330 HKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVD---ISGWVCKTMD 383
            ...||..|..|:..|::|||.||...:.|:.||:|  .:..:.:   :|.|||:.::
Human   385 VGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFI--VQFNDGNAAVVSMWVCRALE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsor1	NP_511098.1	PKc_MEK	85..382	CDD:132946	127/299 (42%)
Dsor1	NP_511098.1	S_TKc	88..364	CDD:214567	121/275 (44%)
MAP2K5	NP_660143.1	PB1_Map2k5	17..107	CDD:99717	4/15 (27%)
		Interaction with MAPK7. /evidence=ECO:0000250	18..25
		Interaction with MAP3K2/MAP3K3. /evidence=ECO:0000250	64..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..144		6/27 (22%)
		Interaction with MAPK7. /evidence=ECO:0000250	117..131		3/13 (23%)
		PKc_MKK5	164..442	CDD:132950	127/302 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566457at33208
OrthoFinder	1	1.000	-	-		FOG0000715
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X438
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820