DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dsor1 and Map2k5

DIOPT Version :9

Sequence 1:	NP_511098.1	Gene:	Dsor1 / 31872	FlyBaseID:	FBgn0010269	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_035970.1	Gene:	Map2k5 / 23938	MGIID:	1346345	Length:	448	Species:	Mus musculus

Alignment Length:	381	Identity:	142/381 - (37%)
Similarity:	220/381 - (57%)	Gaps:	45/381 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EATVAAATVAPTPPF----KTPSGTDTHSL-----LGKPKTSIDALTETLEGLDMGDTERKRIKM 71
            |..|....:.|...|    |.|...:.|.|     .|..:.:...::::|..        ..:|.
Mouse    91 EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPS--------NSLKK 147

  Fly    72 FLSQKEKI---GELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRE 133
            ..::..||   |:::::|:.....||.||||.|.|..|..:..|:|.|:|.|::...::|||:.|
Mouse   148 SSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAHHVPSGKILAVKVILLDITLELQKQIMSE 212

  Fly   134 LKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSY 198
            |::|::|:..:|:||||||:.:..||||.|:|||||||:..|    |||.:||||.:||:|||:|
Mouse   213 LEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----IPEHVLGRIAVAVVKGLTY 273

  Fly   199 LRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQS 263
            |. :..|:||||||||:|||:.|::|:||||||.||::|:|.::|||.:||:|||:.|..|.:.|
Mouse   274 LW-SLKILHRDVKPSNMLVNTGGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHS 337

  Fly   264 DIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPKL 328
            |:||||:|.:|:|:|.:|.|                   |......::...:||..||:|..|.|
Mouse   338 DVWSLGISFMELALGRFPYP-------------------QIQKNQGSLMPLQLLQCIVDEDSPVL 383

  Fly   329 EHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI-RKAELEEVDISGWVCKTMD 383
            ....||..|..|:..|::|||.||...:.|:.||:| :..:.....:|.|||:.::
Mouse   384 PLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNSTVVSMWVCRALE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsor1	NP_511098.1	PKc_MEK	85..382	CDD:132946	128/297 (43%)
Dsor1	NP_511098.1	S_TKc	88..364	CDD:214567	122/275 (44%)
Map2k5	NP_035970.1	PB1_Map2k5	17..107	CDD:99717	4/15 (27%)
		Interaction with MAPK7. /evidence=ECO:0000269\|PubMed:16507987	18..25
		Interaction with MAP3K2/MAP3K3. /evidence=ECO:0000269\|PubMed:12813044, ECO:0000269\|PubMed:16507987	64..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..144		4/35 (11%)
		Interaction with MAPK7. /evidence=ECO:0000269\|PubMed:16507987	117..131		3/13 (23%)
		PKc_MKK5	164..442	CDD:132950	128/300 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	1	1.000	-	-		FOG0000715
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X438
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820