DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsor1 and mek-2

DIOPT Version :9

Sequence 1:	NP_511098.1	Gene:	Dsor1 / 31872	FlyBaseID:	FBgn0010269	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_491087.1	Gene:	mek-2 / 171872	WormBaseID:	WBGene00003186	Length:	387	Species:	Caenorhabditis elegans

Alignment Length:	402	Identity:	204/402 - (50%)
Similarity:	268/402 - (66%)	Gaps:	36/402 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KNKLNLVLPP-VNTEATVAAATVAPTPPFKTPSGTDTHSLLGKPKTSIDALTETLEGLDMGDTER 66
            :|.|.|.||| ||.::....||                   .:..|:...|.|.|:.|.:.:.:.
Worm     7 RNPLGLSLPPTVNEQSESGEAT-------------------AEEATATVPLEEQLKKLGLTEPQT 52

  Fly    67 KRIKMFLSQKEKIGELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQIL 131
            :|:..||..||.|.|||::.|:..||||.||||||.|..|..|.:||||||:|||:||::::||:
Worm    53 QRLSEFLQVKEGIKELSEDMLQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIV 117

  Fly   132 RELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGL 196
            :||.|||:||.|.||||||||..:.:||||||||||.|||::||:.||:||..:|||::||::||
Worm   118 KELAVLHKCNSPFIVGFYGAFVDNNDISICMEYMDGLSLDIVLKKVGRLPEKFVGRISVAVVRGL 182

  Fly   197 SYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV 261
            :||:|...|:||||||||:||||:||||:|||||||.||||||||||||||||:||||.|:||::
Worm   183 TYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYTI 247

  Fly   262 QSDIWSLGLSLVEMAIGMYPIPPPNTATLESIF---------ADNAEESG-QPTDEPRAMAIFEL 316
            .|||||.||||||:.||.||:|.|:.|...::|         ||:.||.. .|...|.:|||||:
Worm   248 SSDIWSFGLSLVELLIGRYPVPAPSQAEYATMFNVAENEIELADSLEEPNYHPPSNPASMAIFEM 312

  Fly   317 LDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVDISG----W 377
            ||||||.|||.|..:.|:.|...||..||:|.|.|||.||:|.:..:.  .:..:.|..|    :
Worm   313 LDYIVNGPPPTLPKRFFTDEVIGFVSKCLRKLPSERATLKSLTADVFF--TQYADHDDQGEFAVF 375

  Fly   378 VCKTMDLPPSTP 389
            |..|::||...|
Worm   376 VKGTINLPKLNP 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsor1	NP_511098.1	PKc_MEK	85..382	CDD:132946	176/310 (57%)
Dsor1	NP_511098.1	S_TKc	88..364	CDD:214567	172/285 (60%)
mek-2	NP_491087.1	PKc_MEK	71..380	CDD:132946	176/310 (57%)
mek-2	NP_491087.1	S_TKc	74..360	CDD:214567	172/285 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160594
Domainoid	1	1.000	352	1.000	Domainoid score	I529
eggNOG	1	0.900	-	-		E1_KOG0581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2063
Inparanoid	1	1.050	376	1.000	Inparanoid score	I1210
Isobase	1	0.950	-	0	Normalized mean entropy	S924
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566457at33208
OrthoFinder	1	1.000	-	-		FOG0000715
OrthoInspector	1	1.000	-	-		oto19822
orthoMCL	1	0.900	-	-		OOG6_100914
Panther	1	1.100	-	-	LDO	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	1	1.000	-	-		X438
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740