DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsor1 and map2k2b

DIOPT Version :9

Sequence 1:	NP_511098.1	Gene:	Dsor1 / 31872	FlyBaseID:	FBgn0010269	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001121753.1	Gene:	map2k2b / 100002225	ZFINID:	ZDB-GENE-080219-34	Length:	395	Species:	Danio rerio

Alignment Length:	388	Identity:	241/388 - (62%)
Similarity:	298/388 - (76%)	Gaps:	20/388 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PTPPFKTPSG---TDTHSLLGKPKTSIDALTETLEGLDMGDTERKRIKMFLSQKEKIGELSDEDL 87
            |.|...|.||   |.:..:....:.:::||.:.|:.||:.:.::||::.||:||..:|||.|:|.
Zfish     7 PDPIVITGSGEAQTTSTPIDAASEANLEALQKKLDELDLDEQQKKRLEAFLTQKANLGELKDDDF 71

  Fly    88 EKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAF 152
            :.:.|||:||||||.||.|..:.|:|||||||||:||||:.||:|||:||||||.|:||||||||
Zfish    72 QHICELGAGNGGVVNKVCHKPSGLVMARKLIHLEIKPAIRHQIIRELQVLHECNSPYIVGFYGAF 136

  Fly   153 YSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILV 217
            |||||||||||.|||||||.:||.|.||||.|||::::|||:||:|||:.|.|||||||||||||
Zfish   137 YSDGEISICMENMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLAYLREKHQIIHRDVKPSNILV 201

  Fly   218 NSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPI 282
            |..||||:|||||||||||||||||||||||||||||||||||||||:||:||||||:|||.|||
Zfish   202 NCRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGRYPI 266

  Fly   283 PPPNTATLESIFA----DNAE-ESGQPTDEPR-----------AMAIFELLDYIVNEPPPKLEHK 331
            |||:...||.||.    |..| |:...:..||           .||||||||||||||||||.|.
Zfish   267 PPPDAKELEGIFGRALMDVGEAETHSTSPRPRPPGRPISGHGPVMAIFELLDYIVNEPPPKLPHG 331

  Fly   332 IFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVDISGWVCKTMDL-PPSTPKRNT 393
            :|:.:|:|||..||.|.|.:|||||.|::|.:|::||:||:|.:||:||||.| .||||.:.|
Zfish   332 VFTPDFQDFVTNCLIKNPADRADLKMLMNHTFIKRAEVEEMDFAGWLCKTMGLNQPSTPTQTT 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsor1	NP_511098.1	PKc_MEK	85..382	CDD:132946	212/312 (68%)
Dsor1	NP_511098.1	S_TKc	88..364	CDD:214567	201/291 (69%)
map2k2b	NP_001121753.1	PKc_MEK	69..382	CDD:132946	212/312 (68%)
map2k2b	NP_001121753.1	S_TKc	71..364	CDD:214567	201/292 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583270
Domainoid	1	1.000	409	1.000	Domainoid score	I663
eggNOG	1	0.900	-	-		E1_KOG0581
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1389
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566457at33208
OrthoFinder	1	1.000	-	-		FOG0000715
OrthoInspector	1	1.000	-	-		otm26205
orthoMCL	1	0.900	-	-		OOG6_100914
Panther	1	1.100	-	-	O	PTHR48013
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X438
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760