DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42726 and ZKSCAN3

DIOPT Version :9

Sequence 1:NP_732017.3 Gene:CG42726 / 318709 FlyBaseID:FBgn0261679 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_001229823.1 Gene:ZKSCAN3 / 80317 HGNCID:13853 Length:538 Species:Homo sapiens


Alignment Length:269 Identity:73/269 - (27%)
Similarity:110/269 - (40%) Gaps:40/269 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 HTKCRLCLVADVSDCLECRVARSVDIQETQETQARTSADKRIIVTDKGYHCTVCNKDF--RSRTQ 86
            |.|....|..|::....|        .|..|.:.|....::.....:.:.|..|.|.|  .|...
Human   274 HGKISCHLREDIAQIPTC--------AEAGEQEGRLQRKQKNATGGRRHICHECGKSFAQSSGLS 330

  Fly    87 QYYHLTCGNDLLKKFNCKECGRRFATSSHLKYHLMSHEKQSKHSCSVCHKSFKQPIVLQRHMLTH 151
            ::..:..|.   |.:.|:|||:.|..||.|..|...|..:..:.|..|.|:|.....|.:|..||
Human   331 KHRRIHTGE---KPYECEECGKAFIGSSALVIHQRVHTGEKPYECEECGKAFSHSSDLIKHQRTH 392

  Fly   152 NQEK-HLCPICQKVFRRKSSLASHLAIHSDLGLQFKCELCSKHFQNKANLNQHLRKH--DKN--- 210
            ..|| :.|..|.|.|.:..||..|..||:. ...::|.:|.|.|:..::|.:|.|.|  |||   
Human   393 TGEKPYECDDCGKTFSQSCSLLEHHRIHTG-EKPYQCSMCGKAFRRSSHLLRHQRIHTGDKNVQE 456

  Fly   211 ----------------NIR----HMCKVCQKSFLRQTTLRLHMKRHSNRERQSCSLCGKSYNDPD 255
                            |:.    :.|..|::||.:.|.|..|.|.|:..:...|:.|||.:....
Human   457 PEQGEAWKSRMESQLENVETPMSYKCNECERSFTQNTGLIEHQKIHTGEKPYQCNACGKGFTRIS 521

  Fly   256 ALGRHLRQH 264
            .|.:|.|.|
Human   522 YLVQHQRSH 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42726NP_732017.3 C2H2 Zn finger 74..94 CDD:275368 5/21 (24%)
C2H2 Zn finger 103..123 CDD:275368 9/19 (47%)
COG5048 <112..288 CDD:227381 53/179 (30%)
C2H2 Zn finger 131..151 CDD:275368 6/19 (32%)
Chordopox_A33R 151..>254 CDD:283591 37/128 (29%)
C2H2 Zn finger 158..178 CDD:275368 7/19 (37%)
C2H2 Zn finger 187..207 CDD:275368 7/19 (37%)
C2H2 Zn finger 216..236 CDD:275368 8/19 (42%)
C2H2 Zn finger 244..264 CDD:275368 7/19 (37%)
C2H2 Zn finger 272..290 CDD:275368
ZKSCAN3NP_001229823.1 SCAN 42..154 CDD:128708
SCAN 42..130 CDD:280241
KRAB 214..274 CDD:214630 73/269 (27%)
KRAB 217..252 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..274 73/269 (27%)
zf-C2H2 314..336 CDD:278523 5/21 (24%)
C2H2 Zn finger 316..336 CDD:275368 5/19 (26%)
zf-H2C2_2 329..351 CDD:290200 6/24 (25%)
C2H2 Zn finger 344..364 CDD:275368 9/19 (47%)
zf-H2C2_2 356..381 CDD:290200 7/24 (29%)
COG5048 <368..515 CDD:227381 42/147 (29%)
C2H2 Zn finger 372..392 CDD:275368 6/19 (32%)
zf-H2C2_2 384..409 CDD:290200 10/24 (42%)
C2H2 Zn finger 400..420 CDD:275368 7/19 (37%)
zf-H2C2_2 412..437 CDD:290200 9/25 (36%)
C2H2 Zn finger 428..448 CDD:275368 7/19 (37%)
zf-C2H2 480..502 CDD:278523 8/21 (38%)
C2H2 Zn finger 482..502 CDD:275368 8/19 (42%)
zf-H2C2_2 495..519 CDD:290200 8/23 (35%)
C2H2 Zn finger 510..530 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23226
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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