DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42726 and ZFP2

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_085116.2	Gene:	ZFP2 / 80108	HGNCID:	26138	Length:	461	Species:	Homo sapiens

Alignment Length:	301	Identity:	82/301 - (27%)
Similarity:	137/301 - (45%)	Gaps:	25/301 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNKCPRCNCDATGQNRLVTDSCGHTKCRLCLVADVSDCLECRVARSVDIQETQETQARTSA---D 62
            |.|.|. ||::.|::.........|: |:.:...:.:|.:|           .:|.:::|:   .
Human    69 MVKRPH-NCNSHGEDATQNSELIKTQ-RMFVGKKIYECNQC-----------SKTFSQSSSLLKH 120

  Fly    63 KRIIVTDKGYHCTVCNKDFRSRTQQYYH--LTCGNDLLKKFNCKECGRRFATSSHLKYHLMSHEK 125
            :||...:|.|.|.||.|.|..|:....|  :..|.   |.:.|.|||:.|:.|.:|..|..:|..
Human   121 QRIHTGEKPYKCNVCGKHFIERSSLTVHQRIHTGE---KPYKCNECGKAFSQSMNLTVHQRTHTG 182

  Fly   126 QSKHSCSVCHKSFKQPIVLQRHMLTHNQEK-HLCPICQKVFRRKSSLASHLAIHSDLGLQFKCEL 189
            :..:.|..|.|:|.:...|.:|...|..|| :.|..|.|.|.:..:|..|...|:. ...::|..
Human   183 EKPYQCKECGKAFHKNSSLIQHERIHTGEKPYKCNECGKAFTQSMNLTVHQRTHTG-EKPYECNE 246

  Fly   190 CSKHFQNKANLNQHLRKHDKNNIRHMCKVCQKSFLRQTTLRLHMKRHSNRERQSCSLCGKSYNDP 254
            |.|.|....:|..|.|.|.... .:.|..|.|:|.:.:||.||.:.|:..:...|:.||||::..
Human   247 CGKAFSQSMHLIVHQRSHTGEK-PYECSQCGKAFSKSSTLTLHQRNHTGEKPYKCNKCGKSFSQS 310

  Fly   255 DALGRHLRQHKTAERYRCIQCDITINRKDNMLRHLRSMHPG 295
            ..|..|.|.|...:.:.|.:|....::..::.:| |.:|.|
Human   311 TYLIEHQRLHSGVKPFECNECGKAFSKNSSLTQH-RRIHTG 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	7/21 (33%)
		C2H2 Zn finger	103..123	CDD:275368	8/19 (42%)
		COG5048	<112..288	CDD:227381	48/176 (27%)
		C2H2 Zn finger	131..151	CDD:275368	6/19 (32%)
		Chordopox_A33R	151..>254	CDD:283591	32/103 (31%)
		C2H2 Zn finger	158..178	CDD:275368	6/19 (32%)
		C2H2 Zn finger	187..207	CDD:275368	7/19 (37%)
		C2H2 Zn finger	216..236	CDD:275368	8/19 (42%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		C2H2 Zn finger	272..290	CDD:275368	3/17 (18%)
ZFP2	NP_085116.2	COG5048	99..451	CDD:227381	74/269 (28%)
		C2H2 Zn finger	104..124	CDD:275368	5/30 (17%)
		C2H2 Zn finger	132..152	CDD:275368	7/19 (37%)
		C2H2 Zn finger	160..180	CDD:275368	8/19 (42%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..292	CDD:275368	8/19 (42%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	328..348	CDD:275368	4/20 (20%)
		C2H2 Zn finger	356..376	CDD:275368
		C2H2 Zn finger	384..404	CDD:275368
		C2H2 Zn finger	412..432	CDD:275368
		C2H2 Zn finger	440..460	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010