DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42726 and ZKSCAN8

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001265048.1	Gene:	ZKSCAN8 / 7745	HGNCID:	12983	Length:	578	Species:	Homo sapiens

Alignment Length:	296	Identity:	87/296 - (29%)
Similarity:	134/296 - (45%)	Gaps:	31/296 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GHT--KCRLCLVADVSDCLECRVARS----VDIQETQETQART-SADK---------------RI 65
            |.|  ||.    .||...||...||.    ::.|....||.|. ..|:               ||
Human   283 GETAAKCN----GDVIRGLEHEEARDLLGRLERQRGNPTQERRHKCDECGKSFAQSSGLVRHWRI 343

  Fly    66 IVTDKGYHCTVCNKDFRSRTQQYYHLTCGNDLLKKFNCKECGRRFATSSHLKYHLMSHEKQSKHS 130
            ...:|.|.|.||.|.|..|:....|....|. :|:::|||||:.|:.::.|..|...|..:..:.
Human   344 HTGEKPYQCNVCGKAFSYRSALLSHQDIHNK-VKRYHCKECGKAFSQNTGLILHQRIHTGEKPYQ 407

  Fly   131 CSVCHKSFKQPIVLQRHMLTHNQEK-HLCPICQKVFRRKSSLASHLAIHSDLGLQFKCELCSKHF 194
            |:.|.|:|.|...|..|...|:.|: :.|..|.|.|...|.|..|..||:. ...::|:.|.|.|
Human   408 CNQCGKAFSQSAGLILHQRIHSGERPYECNECGKAFSHSSHLIGHQRIHTG-EKPYECDECGKTF 471

  Fly   195 QNKANLNQHLRKHDKNNIRHMCKVCQKSFLRQTTLRLHMKRHSNRERQSCSLCGKSYNDPDALGR 259
            :..::|..|.|.|.... .:.|..|.::|.:::.|..|.:.|:......|..|||::|....|.:
Human   472 RRSSHLIGHQRSHTGEK-PYKCNECGRAFSQKSGLIEHQRIHTGERPYKCKECGKAFNGNTGLIQ 535

  Fly   260 HLRQHKTAERYRCIQCDITINRKDNMLRHLRSMHPG 295
            |||.|...:.|:|.:|.....::.:::||.| :|.|
Human   536 HLRIHTGEKPYQCNECGKAFIQRSSLIRHQR-IHSG 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	7/19 (37%)
		C2H2 Zn finger	103..123	CDD:275368	8/19 (42%)
		COG5048	<112..288	CDD:227381	48/176 (27%)
		C2H2 Zn finger	131..151	CDD:275368	7/19 (37%)
		Chordopox_A33R	151..>254	CDD:283591	30/103 (29%)
		C2H2 Zn finger	158..178	CDD:275368	7/19 (37%)
		C2H2 Zn finger	187..207	CDD:275368	7/19 (37%)
		C2H2 Zn finger	216..236	CDD:275368	5/19 (26%)
		C2H2 Zn finger	244..264	CDD:275368	9/19 (47%)
		C2H2 Zn finger	272..290	CDD:275368	4/17 (24%)
ZKSCAN8	NP_001265048.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SCAN	47..159	CDD:128708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..205
		KRAB_A-box	221..>262	CDD:322003
		COG5048	<315..564	CDD:227381	71/251 (28%)
		C2H2 Zn finger	324..344	CDD:275368	2/19 (11%)
		C2H2 Zn finger	380..400	CDD:275368	8/19 (42%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	9/19 (47%)
		C2H2 Zn finger	548..568	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010