DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42726 and ZSCAN21

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001349708.1	Gene:	ZSCAN21 / 7589	HGNCID:	13104	Length:	473	Species:	Homo sapiens

Alignment Length:	284	Identity:	75/284 - (26%)
Similarity:	121/284 - (42%)	Gaps:	41/284 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ECRVARSVDIQETQETQARTSAD--KRIIVTDKGYHCTVCNKDFRSRTQQYYHL----------- 91
            :||:  |...:|:.:.|..:.|:  |..|::     ..:.||...|..:|..:|
Human   198 DCRL--STQHEESADEQKGSEAEGLKGDIIS-----VIIANKPEASLERQCVNLENEKGTKPPLQ 255

  Fly    92 ---------------TCGNDLLKKFNCKECGRRFATSSHLKYHLMSHEKQSKHSCSVCHKSFKQP 141
                           |.|.   :::.|.|||:.|:.||:|..|..:|..:..:.|:.|.|:|...
Human   256 EAGSKKGRESVPTKPTPGE---RRYICAECGKAFSNSSNLTKHRRTHTGEKPYVCTKCGKAFSHS 317

  Fly   142 IVLQRHMLTHNQEKHLCPICQKVFRRKSSLASHLAIHSDLGLQFKCELCSKHFQNKANLNQHLRK 206
            ..|..|..||..::.....|.|.|.:.|.|..|..:|:: ...::|:.|.|.|..|.:|.:|.|.
Human   318 SNLTLHYRTHLVDRPYDCKCGKAFGQSSDLLKHQRMHTE-EAPYQCKDCGKAFSGKGSLIRHYRI 381

  Fly   207 HDKNNIRHMCKVCQKSFLRQTTLRLHMKRHSNRERQSCSLCGKSYNDPDALGRHLRQHKTAERYR 271
            |.... .:.|..|.|||.:...|..|.:.|:..:...|..|||::|......:|.|.|...:.|.
Human   382 HTGEK-PYQCNECGKSFSQHAGLSSHQRLHTGEKPYKCKECGKAFNHSSNFNKHHRIHTGEKPYW 445

  Fly   272 CIQCDITINRKDNMLRHLRSMHPG 295
            |..|..|...|.|:.:|.| :|.|
Human   446 CHHCGKTFCSKSNLSKHQR-VHTG 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	6/45 (13%)
		C2H2 Zn finger	103..123	CDD:275368	9/19 (47%)
		COG5048	<112..288	CDD:227381	51/175 (29%)
		C2H2 Zn finger	131..151	CDD:275368	6/19 (32%)
		Chordopox_A33R	151..>254	CDD:283591	30/102 (29%)
		C2H2 Zn finger	158..178	CDD:275368	6/19 (32%)
		C2H2 Zn finger	187..207	CDD:275368	8/19 (42%)
		C2H2 Zn finger	216..236	CDD:275368	7/19 (37%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..290	CDD:275368	6/17 (35%)
ZSCAN21	NP_001349708.1	SCAN	42..153	CDD:128708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..272		1/27 (4%)
		COG5048	<276..453	CDD:227381	53/178 (30%)
		C2H2 Zn finger	279..299	CDD:275368	9/19 (47%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	337..354	CDD:275368	6/16 (38%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/20 (35%)
		zf-C2H2	446..466	CDD:395048	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010