DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42726 and ZNF18

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001290210.1	Gene:	ZNF18 / 7566	HGNCID:	12969	Length:	549	Species:	Homo sapiens

Alignment Length:	162	Identity:	44/162 - (27%)
Similarity:	74/162 - (45%)	Gaps:	29/162 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 CKECGRRFATSSHLKYHLMSHEKQSKHSCSVCHKSFKQPIVLQRHMLTHNQEKHLCPICQKVFRR 167
            |:|||:.|..:|.|.:|..:|..::...|::|.|:|.:.....:|..||..||.    |
Human   410 CRECGKTFYRNSQLIFHQRTHTGETYFQCTICKKAFLRSSDFVKHQRTHTGEKP----C------ 464

  Fly   168 KSSLASHLAIHSDLGLQFKCELCSKHFQNKANLNQHLRKHDKNNIRHMCKVCQKSFLRQTTLRLH 232
                              ||:.|.|.|.:.:.|..|.:.|.... .:.|.:|:|||::::....|
Human   465 ------------------KCDYCGKGFSDFSGLRHHEKIHTGEK-PYKCPICEKSFIQRSNFNRH 510

  Fly   233 MKRHSNRERQSCSLCGKSYNDPDALGRHLRQH 264
            .:.|:..:...||.||||::...:|.:|.|.|
Human   511 QRVHTGEKPYKCSHCGKSFSWSSSLDKHQRSH 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368
		C2H2 Zn finger	103..123	CDD:275368	8/19 (42%)
		COG5048	<112..288	CDD:227381	39/153 (25%)
		C2H2 Zn finger	131..151	CDD:275368	5/19 (26%)
		Chordopox_A33R	151..>254	CDD:283591	25/102 (25%)
		C2H2 Zn finger	158..178	CDD:275368	1/19 (5%)
		C2H2 Zn finger	187..207	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	9/19 (47%)
		C2H2 Zn finger	272..290	CDD:275368
ZNF18	NP_001290210.1	SCAN	37..148	CDD:322011
		KRAB	<222..249	CDD:307490
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		COG5048	<436..549	CDD:227381	35/136 (26%)
		C2H2 Zn finger	438..458	CDD:275368	5/19 (26%)
		C2H2 Zn finger	466..486	CDD:275368	6/19 (32%)
		zf-H2C2_2	479..503	CDD:316026	8/24 (33%)
		C2H2 Zn finger	494..514	CDD:275368	6/19 (32%)
		zf-H2C2_2	506..530	CDD:316026	8/23 (35%)
		C2H2 Zn finger	522..542	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100