DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42726 and zfx

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	XP_021325975.1	Gene:	zfx / 560346	ZFINID:	ZDB-GENE-061220-2	Length:	739	Species:	Danio rerio

Alignment Length:	269	Identity:	70/269 - (26%)
Similarity:	110/269 - (40%)	Gaps:	20/269 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CLECRVARSVDIQETQETQARTSADKRIIVTDKGYHCTVCNKDFR------SRTQQYYH----LT 92
            |.:|      |....::.......:...:.:...:.|.||.|:|.      |...|::|    |.
Zfish   376 CTDC------DFTTNKKVSLHNHMEIHTLSSKAPFECEVCGKEFHQQAALFSHRLQHHHREAKLQ 434

  Fly    93 CGNDLLKKFNCKECGRRFATSSHLKYHLMS-HEKQSKHSCSVCHKSFKQPIVLQRHMLTHNQEK- 155
            ......|...||.|....|....|..||:: |.|...|.|..|.|.|:.|..|::||.||..||
Zfish   435 ISPPTTKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRTHTGEKP 499

  Fly   156 HLCPICQKVFRRKSSLASHLAIHSDLGLQFKCELCSKHFQNKANLNQHLRKHDKNNIRHMCKVCQ 220
            :.|..|.......|:|.:|:.......:.:||:.|.:.|.....|.||...|::.. .|.|..|.
Zfish   500 YSCLYCDYKSADSSNLKTHVKTKHSKEMPYKCDRCFQTFAEPEELLQHSLTHEEAK-THQCTHCD 563

  Fly   221 KSFLRQTTLRLH-MKRHSNRERQSCSLCGKSYNDPDALGRHLRQHKTAERYRCIQCDITINRKDN 284
            ......:.|:.| :..|:......|.:|||.::.|..|.:|...||..:.::|..|:..|.....
Zfish   564 HKSSNSSDLKRHIISVHTKDYPHKCEVCGKGFHRPSELKKHSAAHKAKKLHQCRHCNFKIADPFV 628

  Fly   285 MLRHLRSMH 293
            :.||:.|:|
Zfish   629 LSRHILSVH 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	9/29 (31%)
		C2H2 Zn finger	103..123	CDD:275368	7/20 (35%)
		COG5048	<112..288	CDD:227381	49/178 (28%)
		C2H2 Zn finger	131..151	CDD:275368	8/19 (42%)
		Chordopox_A33R	151..>254	CDD:283591	26/104 (25%)
		C2H2 Zn finger	158..178	CDD:275368	5/19 (26%)
		C2H2 Zn finger	187..207	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..236	CDD:275368	4/20 (20%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..290	CDD:275368	5/17 (29%)
zfx	XP_021325975.1	Zfx_Zfy_act	27..327	CDD:309717
		C2H2 Zn finger	344..364	CDD:275368
		C2H2 Zn finger	376..396	CDD:275368	3/25 (12%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		C2H2 Zn finger	445..466	CDD:275368	7/20 (35%)
		COG5048	467..>605	CDD:227381	39/138 (28%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
		C2H2 Zn finger	502..523	CDD:275368	5/20 (25%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..580	CDD:275368	4/20 (20%)
		C2H2 Zn finger	588..608	CDD:275368	7/19 (37%)
		C2H2 Zn finger	616..633	CDD:275368	4/16 (25%)
		C2H2 Zn finger	682..703	CDD:275368
		C2H2 Zn finger	711..731	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100