DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42726 and ZNF44

DIOPT Version :9

Sequence 1:NP_732017.3 Gene:CG42726 / 318709 FlyBaseID:FBgn0261679 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_001157748.1 Gene:ZNF44 / 51710 HGNCID:13110 Length:663 Species:Homo sapiens


Alignment Length:376 Identity:103/376 - (27%)
Similarity:142/376 - (37%) Gaps:83/376 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 HT-----KCRLCLVA--DVSD---------------CLECRVARSVDIQETQETQARTSADKRII 66
            ||     :|:.|..|  |.|.               |.:|..|.||        .......:||.
Human   295 HTGEKPYECKQCSKAFPDYSSYLRHERTHTGEKPYKCKQCGKAFSV--------SGSLRVHERIH 351

  Fly    67 VTDKGYHCTVCNKDFRSRTQQYYHL------------TCG---------------NDLLKKFNCK 104
            ..:|.|.|..|.|.|........|:            .||               :.|.|.:.||
Human   352 TGEKPYTCKQCGKAFCHLGSFQRHMIMHSGDGPHKCKICGKGFDFPGSARIHEGTHTLEKPYECK 416

  Fly   105 ECGRRFATSSHLKYHLMSHEKQSKHSCSVCHKSFKQPIVLQRHMLTHNQEK-HLCPICQKVFRRK 168
            :||:..:..|..:.|:|:|.....|.|:||.|:|..|.|.|||..||..|| :.|..|.|.||..
Human   417 QCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGKAFRTS 481

  Fly   169 SSLASHLAIHSDLGLQ-FKCELCSKHFQNKANLNQHLRKHDKNNIRHMCKVCQKSFLRQTTLRLH 232
            |||..|...|:  |.| :||: |.|.|.:..:...|...|.:.. .:.||.|.|:|........|
Human   482 SSLRKHETTHT--GEQPYKCK-CGKAFSDLFSFQSHETTHSEEE-PYECKECGKAFSSFKYFCRH 542

  Fly   233 MKRHSNRERQSCSLCGKSYNDPDALGRHLRQHKTAERYRCIQCDITINRKDNMLRHLRS------ 291
            .:.||..:...|.:|||:::....|..|.|.|...:.|.|.||.........:|||.|:      
Human   543 ERTHSEEKSYECQICGKAFSRFSYLKTHERTHTAEKPYECKQCRKAFFWPSFLLRHERTHTGERP 607

  Fly   292 ---MHPGCAFASTVEMVTPRSS---AQEATTAEERPSQTVRYNSVIQSVGN 336
               .|.|.||:        |||   ..|.|...|:|.:.........|:.:
Human   608 YECKHCGKAFS--------RSSFCREHERTHTGEKPYECKECGKAFSSLSS 650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42726NP_732017.3 C2H2 Zn finger 74..94 CDD:275368 5/31 (16%)
C2H2 Zn finger 103..123 CDD:275368 7/19 (37%)
COG5048 <112..288 CDD:227381 59/177 (33%)
C2H2 Zn finger 131..151 CDD:275368 10/19 (53%)
Chordopox_A33R 151..>254 CDD:283591 34/104 (33%)
C2H2 Zn finger 158..178 CDD:275368 9/19 (47%)
C2H2 Zn finger 187..207 CDD:275368 5/19 (26%)
C2H2 Zn finger 216..236 CDD:275368 6/19 (32%)
C2H2 Zn finger 244..264 CDD:275368 7/19 (37%)
C2H2 Zn finger 272..290 CDD:275368 6/17 (35%)
ZNF44NP_001157748.1 KRAB 52..88 CDD:279668
KRAB 52..>88 CDD:214630
C2H2 Zn finger 192..211 CDD:275368
C2H2 Zn finger 219..239 CDD:275368
COG5048 244..655 CDD:227381 103/376 (27%)
C2H2 Zn finger 247..267 CDD:275368
zf-H2C2_2 260..282 CDD:290200
C2H2 Zn finger 275..295 CDD:275368 103/376 (27%)
zf-H2C2_2 290..310 CDD:290200 4/14 (29%)
C2H2 Zn finger 303..323 CDD:275368 5/19 (26%)
zf-H2C2_2 318..339 CDD:290200 3/20 (15%)
C2H2 Zn finger 331..351 CDD:275368 6/27 (22%)
zf-H2C2_2 343..366 CDD:290200 7/22 (32%)
C2H2 Zn finger 359..379 CDD:275368 5/19 (26%)
C2H2 Zn finger 387..407 CDD:275368 2/19 (11%)
C2H2 Zn finger 415..435 CDD:275368 7/19 (37%)
C2H2 Zn finger 443..463 CDD:275368 10/19 (53%)
zf-H2C2_2 456..480 CDD:290200 11/23 (48%)
C2H2 Zn finger 471..491 CDD:275368 9/19 (47%)
C2H2 Zn finger 499..518 CDD:275368 5/19 (26%)
C2H2 Zn finger 526..546 CDD:275368 6/19 (32%)
C2H2 Zn finger 554..574 CDD:275368 7/19 (37%)
zf-H2C2_2 566..589 CDD:290200 8/22 (36%)
C2H2 Zn finger 582..602 CDD:275368 7/19 (37%)
zf-H2C2_2 595..619 CDD:290200 8/31 (26%)
C2H2 Zn finger 610..630 CDD:275368 8/27 (30%)
zf-H2C2_2 624..647 CDD:290200 4/22 (18%)
C2H2 Zn finger 638..658 CDD:275368 1/13 (8%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5652
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.860

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