DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42726 and ZSCAN22

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001308045.1	Gene:	ZSCAN22 / 342945	HGNCID:	4929	Length:	491	Species:	Homo sapiens

Alignment Length:	234	Identity:	74/234 - (31%)
Similarity:	110/234 - (47%)	Gaps:	16/234 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SDCLECR-VARSVDIQET-QETQARTSADKRIIVTDKGYHCTVCNKDFRSRTQQYYHLTCGNDLL 98
            |.|.||| :.:|....|. |:|.:|.:.          |.|:.|.|.|...|....|...... .
Human   268 SKCRECRKMFQSASALEAHQKTHSRKTP----------YACSECGKAFSRSTHLAQHQVVHTG-A 321

  Fly    99 KKFNCKECGRRFATSSHLKYHLMSHEKQSKHSCSVCHKSFKQPIVLQRHMLTHNQEK-HLCPICQ 162
            |...|||||:.|:..:||..|...|..:..:.|..|.|:|.:...|.:|...|..|: :.|..|.
Human   322 KPHECKECGKAFSRVTHLTQHQRIHTGEKPYKCGECGKTFSRSTHLTQHQRVHTGERPYECDACG 386

  Fly   163 KVFRRKSSLASHLAIHSDLGLQFKCELCSKHFQNKANLNQHLRKHDKNNIRHMCKVCQKSFLRQT 227
            |.|.:.:.|..|..||:. ...:||:.|.:.|.:.:.|.:|||.|.... .:.||||.|:|.:.:
Human   387 KAFSQSTHLTQHQRIHTG-EKPYKCDACGRAFSDCSALIRHLRIHSGEK-PYQCKVCPKAFAQSS 449

  Fly   228 TLRLHMKRHSNRERQSCSLCGKSYNDPDALGRHLRQHKT 266
            :|..|.:.|:..:...||.|||:::...||..|||.|.|
Human   450 SLIEHQRIHTGEKPYKCSDCGKAFSRSSALMVHLRIHIT 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	6/19 (32%)
		C2H2 Zn finger	103..123	CDD:275368	9/19 (47%)
		COG5048	<112..288	CDD:227381	50/156 (32%)
		C2H2 Zn finger	131..151	CDD:275368	6/19 (32%)
		Chordopox_A33R	151..>254	CDD:283591	33/103 (32%)
		C2H2 Zn finger	158..178	CDD:275368	6/19 (32%)
		C2H2 Zn finger	187..207	CDD:275368	7/19 (37%)
		C2H2 Zn finger	216..236	CDD:275368	8/19 (42%)
		C2H2 Zn finger	244..264	CDD:275368	10/19 (53%)
		C2H2 Zn finger	272..290	CDD:275368
ZSCAN22	NP_001308045.1	SCAN	45..133	CDD:307924
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..161
		COG5048	<174..482	CDD:227381	69/226 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..249
		C2H2 Zn finger	270..290	CDD:275368	7/19 (37%)
		C2H2 Zn finger	298..318	CDD:275368	6/19 (32%)
		C2H2 Zn finger	326..346	CDD:275368	9/19 (47%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	8/19 (42%)
		C2H2 Zn finger	466..486	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100