DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42726 and Zfp18

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001012008.1	Gene:	Zfp18 / 303226	RGDID:	1305130	Length:	556	Species:	Rattus norvegicus

Alignment Length:	162	Identity:	42/162 - (25%)
Similarity:	72/162 - (44%)	Gaps:	29/162 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 CKECGRRFATSSHLKYHLMSHEKQSKHSCSVCHKSFKQPIVLQRHMLTHNQEKHLCPICQKVFRR 167
            |:|||:.|..:|.|.:|..:|..::...|.:|.|:|.:.....:|..||..||.    |
  Rat   417 CRECGKTFYRNSQLVFHQRTHTGETYFHCRICKKAFLRSSDFVKHQRTHTGEKP----C------ 471

  Fly   168 KSSLASHLAIHSDLGLQFKCELCSKHFQNKANLNQHLRKHDKNNIRHMCKVCQKSFLRQTTLRLH 232
                              ||:.|.|.|.:.:.|..|.:.|.... .:.|.:|:|||::::....|
  Rat   472 ------------------KCDYCGKGFSDFSGLRHHEKIHTGEK-PYKCPICEKSFIQRSNFNRH 517

  Fly   233 MKRHSNRERQSCSLCGKSYNDPDALGRHLRQH 264
            .:.|:..:...|:.|||.::...:|.:|.|.|
  Rat   518 QRVHTGEKPYKCTHCGKRFSWSSSLDKHQRSH 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368
		C2H2 Zn finger	103..123	CDD:275368	8/19 (42%)
		COG5048	<112..288	CDD:227381	37/153 (24%)
		C2H2 Zn finger	131..151	CDD:275368	5/19 (26%)
		Chordopox_A33R	151..>254	CDD:283591	23/102 (23%)
		C2H2 Zn finger	158..178	CDD:275368	1/19 (5%)
		C2H2 Zn finger	187..207	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..290	CDD:275368
Zfp18	NP_001012008.1	SCAN	37..144	CDD:128708
		SCAN	37..125	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..195
		KRAB_A-box	226..256	CDD:143639
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		COG5048	<428..521	CDD:227381	28/121 (23%)
		zf-H2C2_2	433..454	CDD:290200	6/20 (30%)
		C2H2 Zn finger	445..465	CDD:275368	5/19 (26%)
		zf-H2C2_2	457..481	CDD:290200	10/51 (20%)
		C2H2 Zn finger	473..493	CDD:275368	6/19 (32%)
		zf-H2C2_2	486..510	CDD:290200	8/24 (33%)
		COG5048	497..>549	CDD:227381	14/52 (27%)
		C2H2 Zn finger	501..521	CDD:275368	6/19 (32%)
		zf-H2C2_2	513..537	CDD:290200	6/23 (26%)
		zf-C2H2	527..549	CDD:278523	7/21 (33%)
		C2H2 Zn finger	529..549	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100