DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42726 and ZNF575

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001381166.1	Gene:	ZNF575 / 284346	HGNCID:	27606	Length:	245	Species:	Homo sapiens

Alignment Length:	176	Identity:	54/176 - (30%)
Similarity:	74/176 - (42%)	Gaps:	11/176 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 CKECGRRFATSSHLKYHLMSHEKQSKHSCSVCHKSFKQPIVLQRHMLTHNQEK-HLCPICQKVFR 166
            |.:|.:.|:..|.|..|.::|.....|.|..|.|:|..|..|..|.|||:..: |.||.|.|.|.
Human    65 CPDCDKAFSYPSKLATHRLAHGGARPHPCPDCPKAFSYPSKLAAHRLTHSGARPHPCPHCPKSFG 129

  Fly   167 RKSSLASHLAIHSDLGLQFKCELCSKHFQNKANLNQHLRKHDKNNIR-HMCKVCQKSFLRQTTLR 230
            .:|.||:||..|:.. ..:.|..|.|.|...:.|..|...|...:.| :.|..|.|:|...:.|.
Human   130 HRSKLAAHLWTHAPT-RPYPCPDCPKSFCYPSKLAAHRHTHHATDARPYPCPHCPKAFSFPSKLA 193

  Fly   231 LHMKRHSNRER--------QSCSLCGKSYNDPDALGRHLRQHKTAE 268
            .|...|.....        ..||.||:::.....|..|.|.|...|
Human   194 AHRLCHDPPTAPGSQATAWHRCSSCGQAFGQRRLLLLHQRSHHQVE 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368
		C2H2 Zn finger	103..123	CDD:275368	6/19 (32%)
		COG5048	<112..288	CDD:227381	51/167 (31%)
		C2H2 Zn finger	131..151	CDD:275368	8/19 (42%)
		Chordopox_A33R	151..>254	CDD:283591	32/112 (29%)
		C2H2 Zn finger	158..178	CDD:275368	10/19 (53%)
		C2H2 Zn finger	187..207	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..290	CDD:275368
ZNF575	NP_001381166.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		1/1 (100%)
		PHA03247	<6..211	CDD:223021	45/146 (31%)
		C2H2 Zn finger	67..85	CDD:275368	5/17 (29%)
		C2H2 Zn finger	93..113	CDD:275368	8/19 (42%)
		C2H2 Zn finger	121..141	CDD:275368	10/19 (53%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		C2H2 Zn finger	179..199	CDD:275368	6/19 (32%)
		C2H2 Zn finger	215..235	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100