DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42726 and Zkscan17

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_766529.3	Gene:	Zkscan17 / 268417	MGIID:	2679270	Length:	585	Species:	Mus musculus

Alignment Length:	210	Identity:	68/210 - (32%)
Similarity:	96/210 - (45%)	Gaps:	20/210 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DIQETQETQARTSADKRIIVTDKGYHCTVCNKDFRSRTQQYYHLTCGNDLLKKFNCKECGRRFAT 112
            |:......|:..||:..:..:.|.|.|..|.|.||.|.....||....: .|...|..||..|:.
Mouse   381 DLHSVPAHQSNASAEGEVQTSQKSYVCPNCGKIFRWRVNFIRHLRSRRE-QKPHKCSVCGELFSD 444

  Fly   113 SSHLKYHLMSHEKQSKHSCSVCHKSFKQPIVLQRHMLTHNQEKHLCPICQKVFRR--------KS 169
            |..|..||.:||.|..:.|:.|.|||:    |..|:::| :..||.|..|:..::        :.
Mouse   445 SEDLDGHLETHEAQKPYRCTACGKSFR----LNSHLISH-RRIHLQPASQQPMKKSEEEALETEG 504

  Fly   170 SLASHLAIHSDLGLQFKCELCSKHFQNKANLNQHLRK-HDKNNIR-HMCKVCQKSFLRQTTL--- 229
            :.||.|...|...|.|:|..|.|.||...:|.:|.|. |.|:..| ..|:.|.|:|.:...|
Mouse   505 TGASDLLEKSKAKLSFQCGDCEKSFQRHDHLVRHRRHCHLKDETRPFQCRYCVKTFRQNYDLLRH 569

  Fly   230 -RLHMKRHSNRERQS 243
             ||||||.|.:...|
Mouse   570 ERLHMKRRSKQALNS 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	8/19 (42%)
		C2H2 Zn finger	103..123	CDD:275368	8/19 (42%)
		COG5048	<112..288	CDD:227381	49/146 (34%)
		C2H2 Zn finger	131..151	CDD:275368	7/19 (37%)
		Chordopox_A33R	151..>254	CDD:283591	35/107 (33%)
		C2H2 Zn finger	158..178	CDD:275368	5/27 (19%)
		C2H2 Zn finger	187..207	CDD:275368	8/20 (40%)
		C2H2 Zn finger	216..236	CDD:275368	10/23 (43%)
		C2H2 Zn finger	244..264	CDD:275368	68/210 (32%)
		C2H2 Zn finger	272..290	CDD:275368
Zkscan17	NP_766529.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		SCAN	50..124	CDD:396558
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..167
		KRAB_A-box	221..>249	CDD:413388
		COG5048	<337..573	CDD:227381	61/197 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..397		4/15 (27%)
		C2H2 Zn finger	407..427	CDD:275368	8/19 (42%)
		C2H2 Zn finger	435..455	CDD:275368	8/19 (42%)
		C2H2 Zn finger	463..483	CDD:275368	8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..506		4/22 (18%)
		C2H2 Zn finger	522..543	CDD:275368	8/20 (40%)
		C2H2 Zn finger	553..573	CDD:275368	6/19 (32%)
		Nuclear localization signal	575..579		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100