DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG42726 and ZNF679

DIOPT Version :9

Sequence 1:NP_732017.3 Gene:CG42726 / 318709 FlyBaseID:FBgn0261679 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_699194.2 Gene:ZNF679 / 168417 HGNCID:28650 Length:411 Species:Homo sapiens


Alignment Length:294 Identity:80/294 - (27%)
Similarity:121/294 - (41%) Gaps:24/294 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 CDATGQNRLVTDSCGHTKCRLCLVADVSDCLECRVARSVDIQETQETQARTSADKRIIVTDKG-- 71
            |.:.|:..:....|.          :|:.||.....:.....:..:...:.|...|......|  
Human   128 CKSMGECEVQKGGCN----------EVNQCLSTTQNKIFQTHKCVKVFGKFSNSNRHKTRHTGKK 182

  Fly    72 -YHCTVCNKDFRSRTQQYYHL---TCGNDLLKKFNCKECGRRFATSSHLKYHLMSHEKQSKHSCS 132
             :.|....|.|...:|.:.|.   |..|    .:.|:|||:.|..||.|..|...|..:..:.|.
Human   183 HFKCKKYGKSFCMVSQLHQHQIIHTREN----SYQCEECGKPFNCSSTLSKHKRIHTGEKPYRCE 243

  Fly   133 VCHKSFKQPIVLQRHMLTHNQEK-HLCPICQKVFRRKSSLASHLAIHSDLGLQFKCELCSKHFQN 196
            .|.|:|.....|.:|...|..|| :.|..|.:.|.|.|:||:|..||:. ...:.||.|.|.|..
Human   244 ECGKAFTWSSTLTKHRRIHTGEKPYTCEECGQAFSRSSTLANHKRIHTG-EKPYTCEECGKAFSL 307

  Fly   197 KANLNQHLRKHDKNNIRHMCKVCQKSFLRQTTLRLHMKRHSNRERQSCSLCGKSYNDPDALGRHL 261
            .::|..|.|.|.... .:.|:.|.|:|...:||:.|...|:..:...|..|||::.....|..|.
Human   308 SSSLTYHKRIHTGEK-PYTCEECGKAFNCSSTLKKHKIIHTGEKPYKCKECGKAFAFSSTLNTHK 371

  Fly   262 RQHKTAERYRCIQCDITINRKDNMLRHLRSMHPG 295
            |.|...|.|:|.:||.......::..| :|||.|
Human   372 RIHTGEEPYKCEECDKAFKWSSSLANH-KSMHTG 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42726NP_732017.3 C2H2 Zn finger 74..94 CDD:275368 6/22 (27%)
C2H2 Zn finger 103..123 CDD:275368 9/19 (47%)
COG5048 <112..288 CDD:227381 54/176 (31%)
C2H2 Zn finger 131..151 CDD:275368 6/19 (32%)
Chordopox_A33R 151..>254 CDD:283591 34/103 (33%)
C2H2 Zn finger 158..178 CDD:275368 8/19 (42%)
C2H2 Zn finger 187..207 CDD:275368 8/19 (42%)
C2H2 Zn finger 216..236 CDD:275368 7/19 (37%)
C2H2 Zn finger 244..264 CDD:275368 7/19 (37%)
C2H2 Zn finger 272..290 CDD:275368 4/17 (24%)
ZNF679NP_699194.2 KRAB 16..76 CDD:214630
KRAB 16..55 CDD:279668
C2H2 Zn finger 159..178 CDD:275368 2/18 (11%)
C2H2 Zn finger 186..206 CDD:275368 5/19 (26%)
C2H2 Zn finger 214..234 CDD:275368 9/19 (47%)
zf-H2C2_2 227..250 CDD:290200 6/22 (27%)
COG5048 <238..401 CDD:227381 50/165 (30%)
C2H2 Zn finger 242..262 CDD:275368 6/19 (32%)
zf-H2C2_2 255..279 CDD:290200 8/23 (35%)
C2H2 Zn finger 270..290 CDD:275368 8/19 (42%)
zf-H2C2_2 283..306 CDD:290200 9/23 (39%)
C2H2 Zn finger 298..318 CDD:275368 8/19 (42%)
zf-H2C2_2 310..335 CDD:290200 8/25 (32%)
C2H2 Zn finger 326..346 CDD:275368 7/19 (37%)
zf-H2C2_2 339..362 CDD:290200 7/22 (32%)
C2H2 Zn finger 354..374 CDD:275368 7/19 (37%)
zf-H2C2_2 367..390 CDD:290200 9/22 (41%)
C2H2 Zn finger 382..402 CDD:275368 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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