DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42726 and ZNF275

DIOPT Version :9

Sequence 1:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001354686.1	Gene:	ZNF275 / 10838	HGNCID:	13069	Length:	429	Species:	Homo sapiens

Alignment Length:	331	Identity:	88/331 - (26%)
Similarity:	126/331 - (38%)	Gaps:	66/331 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CLECRVARSVDIQETQETQARTSADKRIIVTDKGYHCTVCNKDFRSRTQQYYH------------ 90
            |.||        .:|...:......:|:...:||:.|..|.|.||...:...|
Human   103 CKEC--------GDTFRLKVLLVQHQRVHSEEKGWECGDCGKVFRGVAEFNEHRKSHVAAEPQPG 159

  Fly    91 --LTCGNDLLKK---------FNCKECGRRFATSSHLKYHLMSHEKQSKHSCSVCHKSFKQPIVL 144
              ....|...|:         |.|:|||:||..::.|..||..|.::....|..|.:|||....|
Human   160 PSRALENAAEKREQMEREAKPFECEECGKRFKKNAGLSQHLRVHSREKPFDCEECGRSFKVNTHL 224

  Fly   145 QRHMLTHNQEK--------------------------HL---CPICQKVFRRKSSLASHLAIHSD 180
            .||...|..||                          ||   |..|.|.||..:.||.|..|||.
Human   225 FRHQKLHTSEKPFACKACSRDFLDRQELLKHQRMHTGHLPFDCDDCGKSFRGVNGLAEHQRIHSG 289

  Fly   181 LGLQFKCELCSKHFQNKANLNQHLRKHDKNNIRHMCKVCQKSFLRQTTLRLHMKRHSNRERQSCS 245
             ...:.|..|.|.|:..:.|.:|.|.|.... .:.|..|.|:|.:.::|..|.:.||.....:|.
Human   290 -AKPYGCPHCGKLFRRSSELTKHRRIHTGEK-PYACGQCGKAFRQSSSLLEHARIHSGERPYACG 352

  Fly   246 LCGKSYNDPDALGRHLRQHKTAERYRCIQCDITINRKDNMLRHLRSMHPG---CAFASTVEMVTP 307
            .|||::..|..|.:|.|.|...:.|.|.:|.....|...:.|| |.:|.|   |..:....:...
Human   353 ECGKAFRGPSDLIKHRRIHSGLKPYECDKCGKAFRRSSGLSRH-RRIHSGARRCECSQCGRVFKR 416

  Fly   308 RSSAQE 313
            ||:.|:
Human   417 RSALQK 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	6/33 (18%)
		C2H2 Zn finger	103..123	CDD:275368	9/19 (47%)
		COG5048	<112..288	CDD:227381	57/204 (28%)
		C2H2 Zn finger	131..151	CDD:275368	8/19 (42%)
		Chordopox_A33R	151..>254	CDD:283591	36/131 (27%)
		C2H2 Zn finger	158..178	CDD:275368	8/19 (42%)
		C2H2 Zn finger	187..207	CDD:275368	7/19 (37%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		C2H2 Zn finger	272..290	CDD:275368	5/17 (29%)
ZNF275	NP_001354686.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..95
ZNF275	NP_001354686.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..176		2/26 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100