Protein Alignment CG42726 and ZNF274

DIOPT Version :10

• Sequence 1: NP_732017.3
• Gene: CG42726 / 318709
• FlyBaseID: FBgn0261679
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: NP_598009.1
• Gene: ZNF274 / 10782
• HGNCID: 13068
• Length: 653
• Species: Homo sapiens
• Alignment Length: 238
• Identity: 63/238 - (26%)
• Similarity: 103/238 - (43%)
• Gaps: 23/238 - (9%)

  Fly    47 VDIQ--ETQETQARTSA-DKRIIVTDKGYHCTVCNKDFRSRTQQ-----------YYHLTCGNDL 97
            |.:|  :..|:||.:.| |...::    .|.....|..|.|..|           .:..:|....
Human   417 VSLQKIDNPESQANSGALDTNQVL----LHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQK 477

  Fly    98 LKKFNCKECGRRFATSSHLKYHLMSHEKQSKHSCSVCHKSFKQPIVLQRHMLTHNQEK-HLCPIC 161
            .|:.|  .|.:.|:.|:.....:..|:......||.|.|.|:.|.....|...|..|: ::|..|
Human   478 AKEGN--GCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDC 540

  Fly   162 QKVFRRKSSLASHLAIHSDLGLQFKCELCSKHFQNKANLNQHLRKHDKNNIRHMCKVCQKSFLRQ 226
            .|.|.:.|||..|..:||. ...|:|:.|.:.|.:::.::||||.|.... .:.|:.|.|:|.:.
Human   541 GKGFVQSSSLTQHQRVHSG-ERPFECQECGRTFNDRSAISQHLRTHTGAK-PYKCQDCGKAFRQS 603

  Fly   227 TTLRLHMKRHSNRERQSCSLCGKSYNDPDALGRHLRQHKTAER 269
            :.|..|.:.|:.....:|:.|||::.....|..|.|.|...:|
Human   604 SHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKR 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	4/30 (13%)
		C2H2 Zn finger	103..123	CDD:275368	3/19 (16%)
		COG5048	<112..288	CDD:227381	46/159 (29%)
		C2H2 Zn finger	131..151	CDD:275368	7/19 (37%)
		C2H2 Zn finger	158..178	CDD:275368	8/19 (42%)
		C2H2 Zn finger	187..207	CDD:275368	7/19 (37%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..290	CDD:275368
ZNF274	NP_598009.1	KRAB	14..73	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..159
		SCAN	157..245	CDD:460417
		KRAB	286..327	CDD:460171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..359
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..414
		COG5048	<389..644	CDD:227381	62/234 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..485		7/38 (18%)
		C2H2 Zn finger	481..501	CDD:275368	4/21 (19%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..585	CDD:275368	7/19 (37%)
		zf-C2H2	591..613	CDD:395048	6/21 (29%)
		C2H2 Zn finger	593..613	CDD:275368	6/19 (32%)
		zf-H2C2_2	605..630	CDD:463886	7/24 (29%)
		C2H2 Zn finger	621..641	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..653		5/15 (33%)