DRSC/TRiP Functional Genomics Resources

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Protein Alignment HNRNPH1 and glo

DIOPT Version :9

Sequence 1:NP_001351154.1 Gene:HNRNPH1 / 3187 HGNCID:5041 Length:472 Species:Homo sapiens
Sequence 2:NP_650120.1 Gene:glo / 41431 FlyBaseID:FBgn0259139 Length:586 Species:Drosophila melanogaster


Alignment Length:570 Identity:165/570 - (28%)
Similarity:243/570 - (42%) Gaps:200/570 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    13 VKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTR-EGRPSGEAFVELESEDEVKLALKKDRE 76
            |::||||||.:..|:..|..:..:.||:.||..:.:| :|:.:|||:||:.|:::|:.|.|.::.
  Fly    51 VRLRGLPWSATHKEILDFLENVNVTNGSAGIHLVTSRVDGKNTGEAYVEVASQEDVEEARKLNKA 115

Human    77 TMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPN-- 139
            :|||||:|||.:...|....::....:.  ||  ..|:|||||:..::::|.:|||||:|..:  
  Fly   116 SMGHRYIEVFTATPKEAKEAMRKISGHG--TA--FVVKLRGLPYAVTEQQIEEFFSGLDIKTDRE 176

Human   140 GITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMA- 203
            ||...:|.:||:||||||||.||:..|:||.:::|:|||||||||:||.||::      |...| 
  Fly   177 GILFVMDRRGRATGEAFVQFESQDDTEQALGRNREKIGHRYIEIFRSSIAEMK------RATGAG 235

Human   204 ---MQRPGPYD--RPGAGRGYNSIGRG-----------------AGFERM--------------- 231
               ..||||||  ..||.||.|..|.|                 .||..:               
  Fly   236 GGVGGRPGPYDIRDRGANRGGNDFGGGRNDWGNNGNFGVGANNMLGFNNLPSLMNSGNFGNNQGG 300

Human   232 ------------RRGAYGGGYGGYDDYN------------------------------GYNDGYG 254
                        ..|.:|||..|.:..|                              |:|.|..
  Fly   301 NNGNFGNNSGPSNFGNFGGGNNGGNSGNFGNDSGNSGNFGNFGNNGGGNFGGNNNGGGGFNSGNN 365

Human   255 F----GSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTG--------------------------- 288
            |    |.:.||.:....|.|.....:.:||: |.|::|                           
  Fly   366 FNSPGGVNNFGNNGGSNFGGNGGGGFNNGGN-FVSSSGVGNFGPIGGGRNNNNGNFGNSGFGNFG 429

Human   289 ---------------------------------------------------HCVHMRGLPYRATE 302
                                                               :.:|||||||.:.|
  Fly   430 GNNNVGSNFGGGNNGGGGGFNNGSNFGGGNSMGGGGNFGPIGGGRGNDIEYYTIHMRGLPYTSFE 494

Human   303 NDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLN-STAG 366
            ||::.||.|:.|..|.|.....|..:|.||..|.|:||:..||.:.:..|..||:|||.: .|.|
  Fly   495 NDVFKFFEPIRPANVRINYNKKGLHSGTADAYFDTYEDSQVAMKRHREQMGSRYIELFYDGKTRG 559

Human   367 ASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQL 416
            .:||  ||          .|.:||       ||||    ::.||..|:::
  Fly   560 LNGG--EH----------GGGNGG-------GGMG----NNGGGNFSRRI 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HNRNPH1NP_001351154.1 RRM1_hnRNPH_hnRNPH2_hnRNPF 10..88 CDD:241173 32/75 (43%)
RRM_SF 93..188 CDD:327398 44/96 (46%)
zf-RNPHF 255..290 CDD:311844 11/116 (9%)
RRM3_hnRNPH_hnRNPH2_hnRNPF 289..364 CDD:241178 32/75 (43%)
gloNP_650120.1 RRM_SF 51..125 CDD:302621 30/73 (41%)
RRM2_hnRNPH_like 146..224 CDD:240948 41/77 (53%)
RRM3_hnRNPH_CRSF1_like 481..555 CDD:240950 32/73 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 78 1.000 Domainoid score I8778
eggNOG 1 0.900 - - E1_KOG4211
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 243 1.000 Inparanoid score I3313
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D392876at33208
OrthoFinder 1 1.000 - - FOG0000855
OrthoInspector 1 1.000 - - otm42118
orthoMCL 1 0.900 - - OOG6_102542
Panther 1 1.100 - - O PTHR13976
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4231
SonicParanoid 1 1.000 - - X436
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.900

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