DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31321 and CG15890

DIOPT Version :9

Sequence 1:	NP_731899.1	Gene:	CG31321 / 318681	FlyBaseID:	FBgn0051321	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001285245.1	Gene:	CG15890 / 32401	FlyBaseID:	FBgn0030576	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	171/577 - (29%)
Similarity:	278/577 - (48%)	Gaps:	95/577 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SGAVDAEPKLNYFQKLWRYRHYLVIEPFFFFYFMASVFNAVAMQNFPLDKACRVNLGYNKIVCDT 79
            :|..:...|.::.:|:....:.:.:||....|.|.||.:.:|.||..|:||||||:.|...|||.
  Fly    48 NGTTNPPVKRSWREKIRLVANNVTVEPILAAYIMPSVLSNLATQNLNLEKACRVNMAYGDEVCDA 112

  Fly    80 MLDKSELGIECDDFDFENTTQGATPDLADLVIGATGFNYTVCKAELEAQILAADVSGKRAPMAAI 144
            :                  |:..|.            |||:  .|...|.:.|.::..:..:.::
  Fly   113 L------------------TRRQTA------------NYTL--EEETVQQMVARMAAWKTVIQSL 145

  Fly   145 FPLIVLLFAGGWADRYNKRKPCMIMPIIGEALSFTCQIISSIFFESLPMEFGAYCEAIVPALFGG 209
            ||.:::||.|.|:||:.:||||:::|::||.|. ...::..::||..|||..|..|||.|:|.||
  Fly   146 FPCLLILFWGSWSDRHRRRKPCILIPVVGEFLG-VVGLMLCVYFEQAPMEAAALTEAIFPSLSGG 209

  Fly   210 LTFCLMAIYSYITIATPEEDRVFRFGIF-AMFVTGVPFIGQPISGVLFTTLGYTWSFASAIVFQL 273
            ....||.::|||...|.||||..|.||. ..|..||| ||...||||...:|:...|:.:..|.:
  Fly   210 WFTMLMGVFSYIADITTEEDRTLRIGILNVCFSVGVP-IGMAFSGVLLKQIGFYGVFSISAAFYV 273

  Fly   274 IAIFYIIFFIKEVKTTPTTSTTANEPPPLPTSLPPKQQGADNMAYETTNLDELQGNKNVNFQLTP 338
            ||..|..||::|                                                    |
  Fly   274 IAFVYGFFFLEE----------------------------------------------------P 286

  Fly   339 QMEPKVEVVPPKRSLLKELFDPTLVLDCIRFPLVKRPNNGRMLLILLLCAYFLTVGPTSGENDYW 403
            |..|  |....::|||.:.||...|:...|....|..|..|..:|||:....:.:||..||....
  Fly   287 QSRP--EKSAEQKSLLADFFDKEHVVQTFRVAFKKGENQRRKRVILLMIVVMVIIGPLHGEMAVT 349

  Fly   404 YRFTLKKLAWNGNDFSIYLTLSSGAALVGTFIGTAILSKLLKVSDSMIGMLSALSIVCSRVLFAF 468
            |.||..:..|:..:||.:.|.:....|:|......|||..|.:.|:::|:||:.|.:.|..::||
  Fly   350 YLFTRFRFNWSEVEFSFFSTYAMFTGLIGVIFCVGILSHKLNIDDALVGVLSSTSKILSSFVYAF 414

  Fly   469 SSSTASFYVAGVVDMFVSLRVIAIKTIGSSIVAGDELSKMYSIFGISEPIAQFIFPPIFSEIYKS 533
            ::.....|:.|:|::|.....||:::|.:.:|:.|||.|:.|:||::|.:...:|.|:::.:|.:
  Fly   415 ATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMVFAPMYTTLYAA 479

  Fly   534 TVDSFPGAIWLFGEIFYIPNVLVFVVCY-FLLRRRK----ANEEKSVVEMEQNGGAN 585
            |:...|||.:|.|....:.:|.:|:..| |.:|:|:    |:.|.:.|: :.||..|
  Fly   480 TLRVLPGAFFLLGGGLTLFSVFIFLWMYRFQVRQRRNLASADAESAAVK-DPNGNIN 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31321	NP_731899.1	MFS	141..>271	CDD:119392	54/130 (42%)
		MFS_1	143..>271	CDD:284993	54/128 (42%)
		MFS	<379..559	CDD:119392	56/179 (31%)
CG15890	NP_001285245.1	MFS	135..507	CDD:119392	130/427 (30%)
CG15890	NP_001285245.1	MFS_1	135..470	CDD:284993	119/390 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458924
Domainoid	1	1.000	94	1.000	Domainoid score	I7409
eggNOG	1	0.900	-	-		E1_KOG2816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4578
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17968at7147
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900