DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dnaaf5 and DNAAF5

DIOPT Version :10

Sequence 1:NP_731905.1 Gene:Dnaaf5 / 318680 FlyBaseID:FBgn0288976 Length:845 Species:Drosophila melanogaster
Sequence 2:NP_060272.3 Gene:DNAAF5 / 54919 HGNCID:26013 Length:855 Species:Homo sapiens


Alignment Length:859 Identity:209/859 - (24%)
Similarity:360/859 - (41%) Gaps:149/859 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KICSDLESSDRRLKTTVLDELLDKCKEATNSESADKIADVFDKLYL-HLLKCYEDRFESVRSKAI 72
            ::...||:..:..:...|:.|....:|...:.........:.:|.| .||:|..|..|..|:.|:
Human    33 RLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAEGCRALAV 97

  Fly    73 QVVSAFL-SSLPPTDFHLMNVVSTLAERMG----KAETVEPSEEIRLLYIAQLNLMI-----CLY 127
            .::...| .:..|.| .|..::..||.|:.    .....|..||:||..:..|.|.:     .|.
Human    98 HLLDLGLRRAARPRD-ALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALA 161

  Fly   128 EKMENVGVFRECYPLVVKILIKSIKDDYPVVQREGCSAVVTLSRLADTQEFRPFTESILLPLYTM 192
            ..:::          .::.|..|:.|.:..|:||.||....|:: |....|...:||::.||...
Human   162 PHLDD----------ALRALRCSLLDPFAAVRRESCSCAAALAQ-ATPDHFHMQSESLIGPLMQT 215

  Fly   193 LNHKHAQARISAIQAIARLSLHMDASGDAMRRLFNEVSPLLMDTMPLVRREVGQMGILMLMELLD 257
            ::|:|.:.|::||:|...: :|. .:|.::..:.:..:..|.|.:|.|||.|..:....|:.|.|
Human   216 ISHQHWKVRVAAIEATGAV-IHF-GNGKSVDDVLSHFAQRLFDDVPQVRRAVASVVGGWLLCLRD 278

  Fly   258 RYSFFERILPLVLCCLKDESPEVLNHIYPQWLKCGIQYFNENEAELSQQ-EISDLPVENYPKDVK 321
            |||||.:::||:|..|.||.|||.......|...|:|:..|||.:|..: :.:.....:||...:
Human   279 RYSFFHKLIPLLLSSLNDEVPEVRQLAASLWEDVGLQWQKENEEDLKDKLDFAPPTPPHYPPHER 343

  Fly   322 RPTIGCRGLVQRSL-RLLQLITRETSDWKDNVRLHALKLLYQFVLHAEAAMTAKFFEIYGDLAHA 385
            ||.:|||.||.|:| ::|..:..:.:||....|:.:.:||...:||||...|.....:...|..|
Human   344 RPVLGCRELVFRNLSKILPALCHDITDWVVGTRVKSAQLLPVLLLHAEDHATQHLEVVLRTLFQA 408

  Fly   386 CIDHVAEVNAEAAKVADLMGRLLSYDAWIDHGFDGLERNARESYMRCFYHMFTASLGGTYEQLMR 450
            |.|..|.|.....:.|:|:|..:|.:.::......|::              |.|..|    |:.
Human   409 CTDEEAAVVQSCTRSAELVGTFVSPEVFLKLILSTLKK--------------TPSASG----LLV 455

  Fly   451 LAKLLR-CTDYSHTLKPGFQHYILKLLNTIVDKTLKINAGQNELEDLY-ESVYVCAIKVMALSSS 513
            ||..:| |.  ...|:|   |     |..|..:..:.:..|....||| |.:.:|   |.||.| 
Human   456 LASAMRGCP--REALQP---H-----LAAIATELAQAHICQASENDLYLERLLLC---VQALVS- 506

  Fly   514 LENVGDEDVNFGQTLIEKMVKLLNTSVPKIHERWFHLALQDVINLDAALEDNAEPVMLLNGLINM 578
               |..||......   :::.:|.|.|          ||.....|....::..:.:.::.| ::.
Human   507 ---VCHEDCGVASL---QLLDVLLTIV----------ALAGATGLRDKAQETMDSLAMVEG-VSS 554

  Fly   579 C------HI-----RATYVH--------DLIEKVKIVFQH-----------------CCDSAQ-- 605
            |      ||     |.|..|        :|::...||.|.                 |...:|  
Human   555 CQDLYRKHIGPLLERVTASHLDWTAHSPELLQFSVIVAQSGPALGEALPHVVPTLRACLQPSQDP 619

  Fly   606 ---VKIFSSLSLATLFWSKTMNVERESSTQMLSEFVSQIVEPYLTWKAGSNAEAMRSLAMATLCA 667
               :|:||.||...|..:.|:|.:.:..: .|......|:.|.|.|.||..|.|:|:.|::.|.|
Human   620 QMRLKLFSILSTVLLRATDTINSQGQFPS-YLETVTKDILAPNLQWHAGRTAAAIRTAAVSCLWA 683

  Fly   668 LAQGAESESVEVLPSLAKYMPSL---LEDRNVTTRHYAIKAVVYFREMS-----VEDLKPLAYAT 724
            |.......:.::.......||.:   ||:.:..||..:.:.:..|.:.|     .|.|..:....
Human   684 LTSSEVLSAEQIRDVQETLMPQVLTTLEEDSKMTRLISCRIINTFLKTSGGMTDPEKLIRIYPEL 748

  Fly   725 MQRMDDPSAGIRILAALAM--------GKLKPKFAETDTEENYEKEVWDAIVKRAMDLLLLYHES 781
            ::|:||.|..:|:.||..:        |.....:.::..:..|.:             ||::.:.
Human   749 LKRLDDVSNDVRMAAASTLVTWLQCVKGANAKSYYQSSVQYLYRE-------------LLVHLDD 800

  Fly   782 PEKDMRAAVAVTLK 795
            ||:.::.|:...||
Human   801 PERAIQDAILEVLK 814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dnaaf5NP_731905.1 HEAT repeat 52..80 CDD:293787 10/29 (34%)
HEAT repeat 91..124 CDD:293787 10/36 (28%)
HEAT 141..280 CDD:441023 45/138 (33%)
HEAT repeat 143..174 CDD:293787 9/30 (30%)
HEAT repeat 184..214 CDD:293787 9/29 (31%)
HEAT repeat 224..254 CDD:293787 8/29 (28%)
DNAAF5NP_060272.3 HEAT 1 71..109 10/37 (27%)
HEAT 165..306 CDD:441023 47/153 (31%)
HEAT repeat 166..192 CDD:293787 8/35 (23%)
HEAT 2 202..240 11/39 (28%)
HEAT 3 241..278 9/36 (25%)
HEAT repeat 246..274 CDD:293787 7/27 (26%)
HEAT 4 280..318 16/37 (43%)
HEAT repeat 285..315 CDD:293787 11/29 (38%)
HEAT 5 354..376 5/21 (24%)
HEAT repeat 359..385 CDD:293787 6/25 (24%)
HEAT 6 377..414 11/36 (31%)
HEAT 7 599..638 8/38 (21%)
HEAT 8 696..734 8/37 (22%)
HEAT repeat 701..731 CDD:293787 7/29 (24%)
HEAT 9 738..776 9/37 (24%)
HEAT repeat 740..772 CDD:293787 8/31 (26%)
HEAT repeat 783..813 CDD:293787 6/42 (14%)
HEAT 10 784..822 8/44 (18%)

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