Protein Alignment Dnaaf5 and Dnaaf5

DIOPT Version :10

• Sequence 1: NP_731905.1
• Gene: Dnaaf5 / 318680
• FlyBaseID: FBgn0288976
• Length: 845
• Species: Drosophila melanogaster
• Sequence 2: NP_001074734.1
• Gene: Dnaaf5 / 433956
• MGIID: 3616079
• Length: 853
• Species: Mus musculus
• Alignment Length: 855
• Identity: 221/855 - (25%)
• Similarity: 367/855 - (42%)
• Gaps: 140/855 - (16%)

  Fly     9 KICSDLESSDRRLKTTVLDELLDKCKEATNSESADKIA--DVFDKLYL-HLLKCYEDRFESVRSK 70
            ::...||:..:..:...|:.|....:||.. ..||..|  ..:.:|.| .||:...|..|..|:.
Mouse    30 RLLPGLETESKLGRRRALEALEQVLEEAVR-PGADSAAFQGPWARLLLPRLLRLLSDPAEGCRAL 93

  Fly    71 AIQVVSAFL-SSLPPTDFHLMNVVSTLAERMGKAETV----EPSEEIRLLYIAQLNLMI-----C 125
            |..::...| .:..|.| .|..::..|:.|:.:.|..    ||.||:||..:..|:|.:     .
Mouse    94 AAHLLDLGLRRAARPRD-ALPRLLPALSARLARPELARPPPEPCEELRLALVQLLHLAVDLGGAA 157

  Fly   126 LYEKMENVGVFRECYPLVVKILIKSIKDDYPVVQREGCSAVVTLSRLADTQEFRPFTESILLPLY 190
            |...:::          .|:.|..::.|.:..|:||||.....|:| |..:.|...:||::.||.
Mouse   158 LAPHLDD----------AVRALRAALLDPFAAVRREGCECAAALAR-ATPEHFHMQSESLIGPLM 211

  Fly   191 TMLNHKHAQARISAIQAIARLSLHMDASGDAMRRLFNEVSPLLMDTMPLVRREVGQMGILMLMEL 255
            ..::|:|.:.|::.|:|..  ::....||:::..:.:..:..|.|.:|.||:.|..:....|:.|
Mouse   212 QTISHQHWKVRVAVIEATG--TVIQFGSGNSVDDVLSHFAQRLFDDVPQVRQAVTSVVGGWLLNL 274

  Fly   256 LDRYSFFERILPLVLCCLKDESPEVLNHIYPQWLKCGIQYFNENEAELSQQ-EISDLPVENYPKD 319
            .|||||..::.||:|....||.||:.......|.|.|:|:..||||:|..: :.:..|..|||:.
Mouse   275 RDRYSFLHKLTPLLLSSFSDEMPEIRQTATSLWEKVGLQWQQENEADLKDKLDFASPPPPNYPEH 339

  Fly   320 VKRPTIGCRGLVQRSL-RLLQLITRETSDWKDNVRLHALKLLYQFVLHAEAAMTAKFFEIYGDLA 383
            ..||.:|||.||.|:| ::|..|..:.:||....|:.|.:||...:||||..:|.....:...|.
Mouse   340 ESRPGLGCRELVFRNLSKVLPAICHDITDWVVGTRVKAAQLLPVLLLHAEDHITQHLEIVLRTLH 404

  Fly   384 HACIDHVAEVNAEAAKVADLMGRLLSYDAWID-------------------HGFDGLERNARESY 429
            .||.|....|.....:.|:|:|..:|.:.::.                   ....|..|||.:.:
Mouse   405 QACTDEEKAVVGSCIRAAELIGTFVSPEVFLKLILAMLKKAPSASGLLILASVIRGCPRNALQPH 469

  Fly   430 MRCF------YHMFTASLGGTYEQLMRL---AKLLRCTDYSHTLKPGFQHYILKLLNTIV----- 480
            :...      .|:...|....|.:.:.|   |.|..|.:........|    |::|.||:
Mouse   470 VTVIATELAQEHICQGSENNLYLEHLLLCVQALLSVCQEDCRAASLQF----LEVLVTIMAVSDA 530

  Fly   481 -------DKTLKINAGQNELEDLYESVYVCAIKVMALSSSL-ENVGDEDVNFGQTLIEKMVKLLN 537
                   .||:...|   |:||:..|..:....|.||...| .:.|:..|:..|.|  |...||.
Mouse   531 VGLEKKAQKTMDTLA---EVEDIPSSQDLYRKHVGALLERLTASHGEWAVHSVQLL--KFTVLLT 590

  Fly   538 TSVPKIHERWFHLALQDVI-NLDAALEDNAEPVMLLNGLINMCHIRATYVHDLIEKVKIVFQHCC 601
            .:.|.:.|     |||.|| .|.|.|:.:.:|           |:|
Mouse   591 QAGPAVGE-----ALQHVIPTLRACLQPSTDP-----------HMR------------------- 620

  Fly   602 DSAQVKIFSSLSLATLFWSKTMNVERESSTQM---LSEFVSQIVEPYLTWKAGSNAEAMRSLAMA 663
                :|:||.||:..|....|:    :|..|.   |...::.|:.|.|.|.||..|.|:|:.|::
Mouse   621 ----LKLFSILSMMLLRPKDTV----DSQGQFRGYLDMVINDILAPNLQWHAGRTAAAIRTAAIS 677

  Fly   664 TLCALAQGAESESVEVLPSLAKYMPSL---LEDRNVTTRHYAIKAVVYFREMSVEDLKPLAY--- 722
            .|.||.......:.:|..:....||.:   |||.:.|||..:.:.:..|.:.|.:.::|..:
Mouse   678 CLWALISSDILSAKQVQEAQETLMPQVLATLEDDSQTTRLMSCRIINMFLKNSGDTMEPEKFLKV 742

  Fly   723 --ATMQRMDDPSAGIRILAALAMGKLKPKFAETDTEENYEKEVWDAIVKRAMDLLLLYHESPEKD 785
              ..::|:||.|..:|:.||.|:..........|.:..|:..|  ..:.|.   ||::.:.||..
Mouse   743 YPELLKRLDDVSNDVRMAAASALLTWLKCIESLDGKSAYQSSV--QFLYRE---LLVHLDDPESA 802

  Fly   786 MRAAVAVTLK 795
            ::..|...||
Mouse   803 IQDTVLEVLK 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dnaaf5	NP_731905.1	HEAT repeat	52..80	CDD:293787	9/29 (31%)
		HEAT repeat	91..124	CDD:293787	11/36 (31%)
		HEAT	141..280	CDD:441023	42/138 (30%)
		HEAT repeat	143..174	CDD:293787	10/30 (33%)
		HEAT repeat	184..214	CDD:293787	8/29 (28%)
		HEAT repeat	224..254	CDD:293787	7/29 (24%)
Dnaaf5	NP_001074734.1	SPS1	<21..196	CDD:440281	44/178 (25%)
		HEAT 1. /evidence=ECO:0000255	69..107		10/39 (26%)
		HEAT	163..311	CDD:441023	44/147 (30%)
		HEAT repeat	165..193	CDD:293787	9/27 (33%)
		HEAT 2. /evidence=ECO:0000255	200..238		9/37 (24%)
		HEAT repeat	205..234	CDD:293787	8/28 (29%)
		HEAT 3. /evidence=ECO:0000255	240..276		8/35 (23%)
		HEAT repeat	243..270	CDD:293787	6/26 (23%)
		HEAT 4. /evidence=ECO:0000255	278..316		15/37 (41%)
		HEAT repeat	357..383	CDD:293787	8/25 (32%)
		HEAT 5. /evidence=ECO:0000255	374..412		13/37 (35%)
		HEAT repeat	396..428	CDD:293787	8/31 (26%)
		HEAT 6. /evidence=ECO:0000255	597..636		7/38 (18%)
		HEAT 7. /evidence=ECO:0000255	694..732		10/40 (25%)
		HEAT repeat	700..728	CDD:293787	9/30 (30%)
		HEAT 8. /evidence=ECO:0000255	736..774		9/42 (21%)
		HEAT repeat	738..775	CDD:293787	9/41 (22%)
		HEAT 9. /evidence=ECO:0000255	782..820		9/35 (26%)
		HEAT repeat	784..813	CDD:293787	7/28 (25%)