DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HEATR2 and dnaaf5

DIOPT Version :9

Sequence 1:	NP_731905.1	Gene:	HEATR2 / 318680	FlyBaseID:	FBgn0051320	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	XP_009302392.3	Gene:	dnaaf5 / 100333660	-ID:	-	Length:	849	Species:	Danio rerio

Alignment Length:	876	Identity:	215/876 - (24%)
Similarity:	398/876 - (45%)	Gaps:	149/876 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ESSDRRLKTTVLDELLDKCKEATNSESADKIADVFDKLYLHLLKCYEDRFESVRSKAIQVVSAFL 79
            |:.::||.:..:.|||. |                  |...||||..|..|:.|..:||::..|:
Zfish    55 ETVEQRLSSGAMQELLG-C------------------LLKPLLKCLSDPAETCRDASIQIIVGFI 100

  Fly    80 SSLPPTDFHLMNVVSTLAERMGKAETVEPSEEIRLLYIAQLNLMICLYEKMENVGVFRECYPLVV 144
            .::|..:..|..::..||:|:|..|.:||:||:||..:..|:|::.:..|  .:..:.|.   ::
Zfish   101 RAVPKPEDCLPYLMPALAQRLGGKEILEPAEELRLALMEMLSLLVEVCGK--QIAPYLED---LI 160

  Fly   145 KILIKSIKDDYPVVQREGCSAVVTLSRLADTQEFRPFTESILLPLYTMLNHKHAQARISAIQAIA 209
            |||.::|.|.:..|::|.|...|::::.. .:.|....||:|.||...::|:|:|.|:||.|||.
Zfish   161 KILQRTISDPFAEVKKESCKCTVSVAQCI-PEHFHLQAESLLKPLLQTISHQHSQVRVSATQAIG 224

  Fly   210 RLSLHMDASGDAMRRLFNEVSPLLMDTMPLVRREVGQMGILMLMELLDRYSFFERILPLVLCCLK 274
            .:..:  ::|..:..:.:.::..|.|..|.||:.|..:....|:.|.||||:|.:::||:|..:.
Zfish   225 AVIQY--SAGKNVDEVLSHLAQRLFDDSPRVRKAVTLVVGDWLLRLPDRYSYFHKLIPLLLTSVS 287

  Fly   275 DESPEVLNHIYPQWLKCGIQYFNENEAELSQQEISDLPVEN-YPKDVKRPTIGCRGLVQRSL-RL 337
            ||.||:.:.....|.:.|.|:..|||.:|..:....||... |....:||.:|||.||.|:| :|
Zfish   288 DEIPEIRSLAENSWKQVGAQWEKENEDDLKDKMDFQLPAPALYTSGGERPGLGCRELVVRNLSKL 352

  Fly   338 LQLITRETSDWKDNVRLHALKLLYQFVLHAEAAMTAKFFEIYGDLAHACIDHVAEVNAEAAKVAD 402
            |..:.|:..||....|:..::||...:||||...|.....:...|.|||.|...:|..:..:.|.
Zfish   353 LPAMGRDIGDWLVQTRVKTVQLLRVLLLHAEDHCTQHLQMLLTVLYHACADAETDVRTQCLESAK 417

  Fly   403 LMGRLLSYDAWIDHGFDGLERNARESYMRCFYHMFTASLGGTYEQLMRLAKLLRCTDYSHTLKPG 467
            |:|..:|.:.::......:|.::            :.|....:..||.|..:|..:. ..||:|
Zfish   418 LLGVFVSPEVYLKLLLPHVEDSS------------SCSSASPWAPLMVLGAVLSGSS-RETLRP- 468

  Fly   468 FQHYILKLLNTIVDKTLKINAGQNELEDLY-ESVYVCAIKVMALSSSLENVGDEDVN-FGQTLIE 530
               :::|:.:|:....:.:.:.|    .|| :.:.||...|:       .||.:|.: ....|::
Zfish   469 ---HLVKIGDTLAQPEVCLGSQQ----VLYVDQLLVCVDAVL-------GVGQQDCDVISLQLLK 519

  Fly   531 KMVKLLNTSVPKIHERWFHLALQDVINLDAALEDNAEPVMLLNGLINMCHIRATYVHDL------ 589
            .:|.:  .||...||:  |...::::          ..|.....|..:|.:...::.||
Zfish   520 VLVSV--QSVASQHEQ--HSKAEELL----------RSVCAAQALSGVCDLYRQHMADLLQWLSD 570

  Fly   590 ---------IEKVKI--------------------VFQHCCDSA-----QVKIFSSLSLATLFWS 620
                     |:|.::                    :.:.|.|.:     ::.||:.||...|...
Zfish   571 SHQTWTSFSIQKTQLEIIAMQSGPVVGEFLPALLPLLKSCVDPSREPEMRLHIFTMLSKLLLDAK 635

  Fly   621 KTMNVERESSTQMLSEFVSQ-IVEPYLTWKAGSNAEAMRSLAMATLCALAQG----AESESVEVL 680
            .|::.:.:....|  |.|.| ::.|.|.|::|.:|.|:|:.|::.|.|:..|    || ..|..:
Zfish   636 NTLDSQGQFGEHM--EMVLQDLLMPNLVWRSGRSAAAVRTAALSCLLAVLHGEAFPAE-RVVSAV 697

  Fly   681 PSLAKYMPSLLEDRNVTTRHYAIKAV-----VYFREMSVEDLKPLAYATMQRMDDPSAGIRILAA 740
            .||:..:.|.||:.:...|..|.:::     :..:::|.:.|..:....::|:||.|..:|:.|.
Zfish   698 DSLSSLLISALEEDSKLARLLACRSLTSLLKITAQQISTDKLNQVYPELLKRVDDSSEDVRVEAL 762

  Fly   741 -------LAMGKLKPKFAETDTEENYEKEVWDAIVKRAMDLLLLYHESPEKDMRAAVAVTLKVLA 798
                   .::||            ||:.:.....::.....||||.:.|:..::..|...|||.:
Zfish   763 KSLSVWFCSLGK------------NYDMQSNRPHLELLFQQLLLYMDDPDTTVQNTVLGVLKVAS 815

  Fly   799 KSHPEAWEERYQRALPMAQKKDLLTELYDKL 829
            ....:..:::.:    ..::|....|..|||
Zfish   816 AVDGDLLQQQTE----SVREKQRSPEYCDKL 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HEATR2	NP_731905.1	HEAT repeat	52..80	CDD:293787	11/27 (41%)
		HEAT repeat	91..124	CDD:293787	13/32 (41%)
		HEAT repeat	143..174	CDD:293787	9/30 (30%)
		HEAT repeat	184..214	CDD:293787	13/29 (45%)
		HEAT repeat	224..254	CDD:293787	7/29 (24%)
dnaaf5	XP_009302392.3	HEAT repeat	114..139	CDD:293787	11/24 (46%)
		HEAT repeat	159..187	CDD:293787	9/27 (33%)
		HEAT repeat	199..229	CDD:293787	13/29 (45%)
		HEAT repeat	237..263	CDD:293787	6/25 (24%)
		HEAT repeat	351..377	CDD:293787	8/25 (32%)
		HEAT repeat	390..415	CDD:293787	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41198
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123510at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010