DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GLR3.3

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001322169.1	Gene:	GLR3.3 / 840859	AraportID:	AT1G42540	Length:	933	Species:	Arabidopsis thaliana

Alignment Length:	645	Identity:	134/645 - (20%)
Similarity:	243/645 - (37%)	Gaps:	171/645 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 HWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISP 381
            :|||....:..||.:....:.|        |:|.       ..|.....|.        .||.:.
plant   412 YWSNHSGLSTVLPELLYTKEKP--------NMST-------SPKLKHVIWP--------GETFTK 453

  Fly   382 AR--------RFFRIGTAESIPW-SYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEF 437
            .|        :..:||....:.: .::.:..||..:         ::|:|||........|.:..
plant   454 PRGWVFSNNGKELKIGVPLRVSYKEFVSQIRGTENM---------FKGFCIDVFTAAVNLLPYAV 509

  Fly   438 EI---------VAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYE 493
            .:         ..|...||.|:...|.:||||||:.            :.:.|.:::||..||..
plant   510 PVKFIPYGNGKENPSYTHMVEMITTGNFDGVVGDVA------------IVTNRTKIVDFTQPYAA 562

  Fly   494 QTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC 558
            ...:.:|..|.: .:..:.|:......:|.......:...|::|.::..:     |:....|...
plant   563 SGLVVVAPFKKL-NSGAWAFLRPFNRLMWAVTGCCFLFVGIVVWILEHRT-----NDEFRGPPKR 621

  Fly   559 REFTLRESFWFALTSFTPQGGGEAPKAIS--GRMLVAAYWLFVVLML-ATFTANLAAFLTVERMQ 620
            :..|:   .||   ||:..........:|  || ||...||||||:: :::||:|.:.|||:::.
plant   622 QCVTI---LWF---SFSTMFFAHRENTVSTLGR-LVLIIWLFVVLIINSSYTASLTSILTVQQLS 679

  Fly   621 TPVQSLEQL-ARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPI 684
            :|::.:|.| .|...|.|.|            ..|||..|.   .||.::.|:
plant   680 SPIKGIESLRERDDPIGYQV------------GSFAESYLR---NELNISESR------------ 717

  Fly   685 KEQYGHILLAINSSQPVADA-KEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQ 748
                   |:.:.:.:..|.| |:|     ..:....|.:.:...::..::.||....||:.|.:.
plant   718 -------LVPLGTPEAYAKALKDG-----PSKGGVAAIVDERPYVELFLSSNCAYRIVGQEFTKS 770

  Fly   749 PYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYW---NQSNLPNCPLSEDQEGITLESLGGV 810
            .:..|..:.|.|..:||.|||||.::...:.:..| |   |...|.|..|..|:  :.|:|..|:
plant   771 GWGFAFPRDSPLAIDLSTAILELAENGDLQRIHDK-WLMKNACTLENAELESDR--LHLKSFWGL 832

  Fly   811 FIATLFGLVLAMMTLGMEVL--YYKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWH 873
            |:......:||:....::::  .|||           |.:|              |.:..:|..|
plant   833 FLICGVACLLALFLYFVQIIRQLYKK-----------PTDD--------------AIARDQQQNH 872

  Fly   874 IPVLEAEEKPAKVSPPPSFETATFRGKKLPARITLGDGKFKPRHGLYARRNLGASDSHSG 933
                               ::::.|..:|...::|.|.|.:.:|....|:..|:.:..||
plant   873 -------------------DSSSMRSTRLQRFLSLMDEKEESKHESKKRKIDGSMNDTSG 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	93/428 (22%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	73/305 (24%)
GLR3.3	NP_001322169.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910