DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and GLR2.4

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001328410.1	Gene:	GLR2.4 / 829299	AraportID:	AT4G31710	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	922	Identity:	169/922 - (18%)
Similarity:	324/922 - (35%)	Gaps:	268/922 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TDIAMVLKELDALRLDVKVDD---------TTLTLTRSED----------GLDMQRFCEILSTVG 81
            ||:......|..|.:::.:.|         |.|.|..::.          .||:.:..|:.:.:|
plant    61 TDVGTTASNLSLLAINMSLSDFYSSRPESRTRLLLNFADSRDDVVGAAAAALDLIKNKEVKAILG 125

  Fly    82 ------ASAVID---------LTYSHWEEGYNLVRSLGIGYVRLERIMRPFLD----------MF 121
                  ||.||:         :::|                     ...||||          .:
plant   126 PRTTMQASFVIEVGQKSQVPIISFS---------------------ATSPFLDSGRSPYFFRSTY 169

  Fly   122 GDFMRQKRANNVAMVFMNARDAV-----------------EAMQQMLVGYPFRTLIMDASQTDPG 169
            .|..:.:..:.:..|| ..|:.|                 :|:|.:.:..|:||:|...:..|..
plant   170 DDSSQVQAISEIIKVF-GWREVVPVYENNAFGEGIMPGLTDALQAINIRIPYRTVISPNATDDEI 233

  Fly   170 QHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEW--------HFVFLDTRDRVF 226
            ...|.::.: :|...::....|..| :.:|.|.::..|.::...|        |.|.::..| :.
plant   234 SVDLLKLMT-KPTRVFVVHMNRFLA-SRVFSKARETGLMKQGYAWILTNGVIDHLVLMNGTD-IE 295

  Fly   227 KYRRQAELCTRFTLNPR------AICRSMPMPDL-------YCGS---GFTMQRAMLLNVLRSLI 275
            ..:....:.|.|.::..      .:.::.|:.:|       |..:   ...::.|...|:..|.:
plant   296 AMQGVIGIRTHFPISEELQTFRSRLAKAFPVSELNIYGLRAYDATTALAMAVEEAGTTNLTFSKM 360

  Fly   276 NAAQVSPGYPLAIYQ-DCNATASSSEVSDPLEKDDYNWLD-MVHWSNFLAYAPPLPHIQDQFQSP 338
            :...:|....|::.: ......|.|::.......||:::| .:|.|.|            :..:.
plant   361 DGRNISDLEALSVSEYGPKLIRSLSQIQFKGLSGDYHFVDGQLHASVF------------EIVNV 413

  Fly   339 VPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRL-------LNETISPARRFFRIGTAESIPW 396
            :.|    ..|..|:::.:.....||:  .|.|..|.       ||..:.|       |...::|.
plant   414 IDG----GGILVGFWTQDKGLVKDLS--PSSGTTRTFSSWKNHLNPILWP-------GITLTVPK 465

  Fly   397 SYLRREEGTGELIRDRSGLP-------------------IWEGYCIDFIIRLSQKLNFEFEIVAP 442
            .:.....|. ||   :.|:|                   |..|:||||...:.|.:.:
plant   466 GWEIPTNGK-EL---QIGVPVGTFPQFVKVTTDPLTHETIVTGFCIDFFEAVIQAMPY------- 519

  Fly   443 EVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQ-TGISIAIRKPVR 506
            :|.|  .....|:.||...|..            :.:.|...:||..||... .|:.:.::..|.
plant   520 DVSH--RFIPFGDDDGKTNDTT------------ILANRSSYVDFTLPYTTSGVGMVVPLKDNVA 570

  Fly   507 RTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYACREFT------LRE 565
            |:||. |...|...:|...:.:......::|.::      .|.|        .|||      :..
plant   571 RSSLI-FFKPLTPGLWGMTLGSFFVVGFVVWILE------HRVN--------SEFTGPPQYQIST 620

  Fly   566 SFWFA--LTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLA-TFTANLAAFLTVERMQTPVQSLE 627
            .||||  :..|.|:   |...:.:.|::|.. |.|:||:|. ::||:|::.||.:::.....|::
plant   621 MFWFAFSIMVFAPR---ERVMSFTARVVVIT-WYFIVLVLTQSYTASLSSLLTTQQLNPTETSIK 681

  Fly   628 Q-LARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHI 691
            . ||:...:.|.  :||     ||..|..|               ..|.:.|:..:...|:...:
plant   682 NVLAKGGPVAYQ--RDS-----FVLGKLRE---------------SGFPESRLVPFTSPEKCEEL 724

  Fly   692 LLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEV-FAEQPYAVAVQ 755
            |   |...........|..|              ..::..:.:.|...::.|| |....:.....
plant   725 L---NKGPSKGGVSAAFMEV--------------PYVRVFLGQYCKKYKMVEVPFDVDGFGFVFP 772

  Fly   756 QGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQ---------EGITLESLGGVF 811
            .||.|..::|.|||::.:.....:|:.. |.::....||...:.         ..::|:|...:|
plant   773 IGSPLVADVSRAILKVAESNKATQLETA-WFKNIDKTCPDPMNNPDPNPTVSFRKLSLDSFLLLF 836

  Fly   812 IATLFGLVLAMM 823
            :|......||::
plant   837 VAAATVCTLALL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	87/433 (20%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	62/317 (20%)
GLR2.4	NP_001328410.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910