DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GLR1.4

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	923	Identity:	175/923 - (18%)
Similarity:	327/923 - (35%)	Gaps:	292/923 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TDIAMVLKEL----DALRLDVKVDDTTLTLTRSEDG---------LDMQRFCEILSTVGASAVID 87
            |.|:|.|.:.    :..|..|.|      |:|...|         :|:.:..::.:.||..:::
plant    64 TSISMALSDFYHVNNGYRTRVSV------LSRDSHGDPLQALAAAMDLLQTEQVEALVGGQSLL- 121

  Fly    88 LTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMF-----------GDFMR-----QKRANNVAMV 136
                   |..||. .||      |:...|.:..|           ..|::     ...|..:|.:
plant   122 -------EAKNLA-ELG------EKTKVPVISSFQVPSSLSLAKYNYFIQATHDTSSEAKGIAAL 172

  Fly   137 FMNA--RDAV----------EAMQQMLVGYPFRTLI-----MDASQTDPGQHFLERIRSLRPA-- 182
            |.|.  |.||          |::|. |||:..:..|     .:.|.:...:..::::|..:.:
plant   173 FSNFDWRTAVLIYEDDDDWRESIQP-LVGHFQQNAIHIEYKAEFSVSSNEECIMKQLRKFKASGI 236

  Fly   183 PTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFV------FLDT----RDRV-----FK-YRRQ 231
            ..::|..:...| |.:|...::..:.:....|...      |.||    ::.:     || |...
plant   237 RIFVAHISERIA-NRLFPCARRLGMMEEGYAWILTARSMNNFQDTNYLAKEEMEGVIGFKSYIPL 300

  Fly   232 AELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVS--PGYPLAIYQDCNA 294
            .|....|||..:   ||:.:.::.  :..::......::..||..||:|:  ||  |::|....|
plant   301 TEELHNFTLRWK---RSLRLEEVV--TRMSVCSIWAHDIAWSLARAAEVAKLPG--LSVYDLLEA 358

  Fly   295 TASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEA 359
            ...|::...  ...|..::|.             ..|.|:|:        .||:..       ..
plant   359 IPESAKHKG--LSGDIKFIDK-------------KFISDKFE--------IVNMIG-------RG 393

  Fly   360 KTDLAAWSSVGEMRLLNETISPARRFFRIGTA---ESIPW-----------SYLRREEGTGELIR 410
            :..:..|:|       ...||..||  |:.:.   |:|.|           |...:..|..:.:|
plant   394 ERSVGLWNS-------GSFISNRRR--RLSSTKALETIIWPGGSTRIPKIRSLKEKRHGKKKKLR 449

  Fly   411 ------------------DRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWD 457
                              .::|:....|||||.........|:|.|.:              .|.
plant   450 VLVPAGNITPQILEVKTDFKTGVTAATGYCIDVFETSILPFNYEVEYI--------------PWP 500

  Fly   458 GVV-----GDLV------RGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLF 511
            |.:     .|||      :.:.|.|:..:.:...|...:||..|:.:. |:::...|......:|
plant   501 GAINYKNYNDLVYTLYSQKDKYDAAVGDITITDNRSLYVDFTLPFTDM-GLAVVTAKDKSMWIIF 564

  Fly   512 KFMTVLRLEVWLSIVAALVGTAIMIWFMDKY-------SPYSSRNNRQAYPYACREFTLRESFWF 569
            |.:|   |.:||:|.:..:.|..::|.::::       |.:........:.::...|..||....
plant   565 KPLT---LSLWLTIASFFILTGAIVWLIERHDNADFQGSCFQQIGTLLCFGFSTLVFAHRERLQH 626

  Fly   570 ALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLML-ATFTANLAAFLTVERMQTPVQSLEQLA-RQ 632
            .::.|                 |...|:|.||:| :.:||.|.:.:||:::: .::|.|.:. ..
plant   627 NMSRF-----------------VVIVWIFAVLILTSNYTATLTSVMTVQQIR-GLKSNENIGFFS 673

  Fly   633 SRINYTVVKDSDTHQ--YFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAI 695
            :.|...||.|:.|.|  .:..:|.|:|
plant   674 ASIAANVVNDNPTFQGPRYKGLKTADD-------------------------------------- 700

  Fly   696 NSSQPVADAKEGFANVDAHENADYAFIHDSAE-IKYEITRNCN---LTEVGEVFAEQPYAVAVQQ 756
                        |.|  |..|...:||.|... :|..:.::.:   :.|...|  ...:..|.|:
plant   701 ------------FTN--ALRNGTISFIVDEVPYVKLFVAKHPSEFVIVETESV--TNGFGFAFQK 749

  Fly   757 GSHLGDELSYAILELQKDRFFEELKA--KYWNQSNLPNCPLSEDQEGITLESLGGVFIAT----L 815
            ||.|..::|   .|::|.|..|:|||  .:|.|....:....:....:|:.:..|:|:.|    .
plant   750 GSPLVQKVS---REIEKLRRTEKLKAIENWWFQRQTTSATSEDTFHPLTVYTFRGLFMITGVSFA 811

  Fly   816 FGLVLAMMTLGME 828
            |.|::.::....|
plant   812 FALIVYLIPWNRE 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	90/462 (19%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	62/318 (19%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	76/412 (18%)
		ANF_receptor	64..390	CDD:279440	72/378 (19%)
		GluR_Plant	448..778	CDD:270404	82/422 (19%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	44/215 (20%)
		Lig_chan	570..810	CDD:278489	61/314 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910