DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GLR1.1

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_187061.1	Gene:	GLR1.1 / 819566	AraportID:	AT3G04110	Length:	808	Species:	Arabidopsis thaliana

Alignment Length:	954	Identity:	180/954 - (18%)
Similarity:	326/954 - (34%)	Gaps:	299/954 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELPLLVLLLALRFAG-----------SEV-LKITFWIEPVQRAEFDTDIAMVLKELDAL----- 48
            ||:...:.:|||.|:|           .|| :.:...:..:|....:|...:.|.:...:
plant     1 MEILFSISILALLFSGVVAAPSDDDVFEEVRVGLVVDLSSIQGKILETSFNLALSDFYGINNGYR 65

  Fly    49 -RLDVKVDDT----TLTLTRSED-----------GLDMQRFCEILSTVGASAVIDL--------- 88
             |:.|.|.|:    .:.|..:.|           |....:..::|:|:...|.:.:
plant    66 TRVSVLVRDSQGDPIIALAAATDLLKNAKAEAIVGAQSLQEAKLLATISEKAKVPVISTFLPNTL 130

  Fly    89 ---TYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEAMQQM 150
               .|.::.:..:...|...|...|          ..||    ...:|.:::.:|.|..|::|.:
plant   131 SLKKYDNFIQWTHDTTSEAKGITSL----------IQDF----SCKSVVVIYEDADDWSESLQIL 181

  Fly   151 LVGYPFRTLIMDASQ----TDPGQ-HFLERIRSLRPA-PTYIALFARAAAMNGIFEKVQKADLFQ 209
            :..:..:.:.:..|.    :..|: |.:.::|.|:.: .:...:......::.:|:.|:|..|.:
plant   182 VENFQDKGIYIARSASFAVSSSGENHMMNQLRKLKVSRASVFVVHMSEILVSRLFQCVEKLGLME 246

  Fly   210 RPLEW-----------HFVFLDTRDRV--FK-YRRQAELCTRFTLNPR------------AICRS 248
            ....|           ||....:...|  || |...:|....||...|            ::...
plant   247 EAFAWILTARTMNYLEHFAITRSMQGVIGFKSYIPVSEEVKNFTSRLRKRMGDDTETEHSSVIIG 311

  Fly   249 MPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWL 313
            :...|:.|             :|.:.:....||           ....:||.||..|       |
plant   312 LRAHDIAC-------------ILANAVEKFSVS-----------GKVEASSNVSADL-------L 345

  Fly   314 DMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSE--------HEAKTDLAAWSSVG 370
            |.:..|.|                  .||:..:.||...:.||        .|.:..:..||
plant   346 DTIRHSRF------------------KGLSGDIQISDNKFISETFEIVNIGREKQRRIGLWS--- 389

  Fly   371 EMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIR------------------DRSGLPI 417
                 ..:.|..|:....|.:..||...:..|:|..:::|                  ..:|:..
plant   390 -----GGSFSQRRQIVWPGRSRKIPRHRVLAEKGEKKVLRVLVTAGNKVPHLVSVRPDPETGVNT 449

  Fly   418 WEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGEL-----NELGEWDGVVGDLVRGETDFAIAALKM 477
            ..|:|::.........|:|.|.: |..|:...|     .:..::|..|||:.            :
plant   450 VSGFCVEVFKTCIAPFNYELEFI-PYRGNNDNLAYLLSTQRDKYDAAVGDIT------------I 501

  Fly   478 YSEREEVIDFLPPYYEQTGISIAIRKPVRRT-SLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDK 541
            .|.|...:||..||   |.|.|.|....::: .::.|.......:||:..|..|.|.|::|.::
plant   502 TSNRSLYVDFTLPY---TDIGIGILTVKKKSQGMWTFFDPFEKSLWLASGAFFVLTGIVVWLVE- 562

  Fly   542 YSPYSSRNNRQAYPYACREF------TLRESFWFALTS--FTPQGGGEAPKAISGRMLVAAYWLF 598
                     |...|    ||      .|....||..::  |..:   |..:.:|.|.||.. |:|
plant   563 ---------RSVNP----EFQGSWGQQLSMMLWFGFSTIVFAHR---EKLQKMSSRFLVIV-WVF 610

  Fly   599 VVLML-ATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRM 662
            |||:| ::::|||.:..|:.|||.                       .||    |.|...|....
plant   611 VVLILTSSYSANLTSTKTISRMQL-----------------------NHQ----MVFGGSTTSMT 648

  Fly   663 WKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAE 727
            .|..::||              .|.|..:|            ::|..|...:|....:.:..:..
plant   649 AKLGSINA--------------VEAYAQLL------------RDGTLNHVINEIPYLSILIGNYP 687

  Fly   728 IKYEIT-RNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLP 791
            ..:.:| |..|....|.:|         |:||.|..::|..|.:|:.....::::.|::.:.:..
plant   688 NDFVMTDRVTNTNGFGFMF---------QKGSDLVPKVSREIAKLRSLGMLKDMEKKWFQKLDSL 743

  Fly   792 N--------CPLSEDQEG---ITLESLGGVFI--ATLFGLVLAM 822
            |        ...::|.|.   .|...|.|:||  .....||||:
plant   744 NVHSNTEEVASTNDDDEASKRFTFRELRGLFIIAGAAHVLVLAL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	91/436 (21%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	68/320 (21%)
GLR1.1	NP_187061.1	PBP1_GABAb_receptor	31..397	CDD:107361	68/436 (16%)
		ANF_receptor	45..377	CDD:279440	63/394 (16%)
		Periplasmic_Binding_Protein_Type_2	421..737	CDD:304360	85/411 (21%)
		Lig_chan	542..781	CDD:278489	68/318 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910