DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GLR5

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_565744.1	Gene:	GLR5 / 817801	AraportID:	AT2G32400	Length:	921	Species:	Arabidopsis thaliana

Alignment Length:	931	Identity:	181/931 - (19%)
Similarity:	325/931 - (34%)	Gaps:	252/931 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FAGSEVL--KITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTTLTL--------TRSEDGL 68
            |...|:|  ::...|.|:..:...| |:.:.|.|....:.....|.||:.        |...|..
plant    86 FGAFELLEKEVVAMIGPISSSVAHT-ISDIAKGLHFPLVSFAATDPTLSALQFPFFLRTTPNDAH 149

  Fly    69 DMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNV 133
            .|....::::..|...||.: ||..|.|.|.|.:|                  .|.:.:||:.
plant   150 QMSALVDLINFYGWKEVISV-YSDDELGRNGVSAL------------------DDELYKKRSR-- 193

  Fly   134 AMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGI 198
              :......:|.:.::.|.                  :.|.:.:|:.|. .||..|.....:. |
plant   194 --ISYKVPLSVHSDEKFLT------------------NALNKSKSIGPR-VYILHFGPDPLLR-I 236

  Fly   199 FEKVQKADLFQR-----PLEWHFVFLDT-RDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCG 257
            |:..||..:...     ..:|..|.||: .|:....|.:..:..|     :.|..|:.|
plant   237 FDIAQKLQMMTHEYVWLATDWLSVTLDSLSDKGTLKRLEGVVGLR-----QHIPESVKM------ 290

  Fly   258 SGFT----MQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSE-------VSDPLEKDDY- 310
            ..||    ..|:|....|.:......::.|....:.:..|.|.|.||       ....|||..:
plant   291 EHFTHKLQSNRSMNAYALHAYDTVWMIAHGIEELLNEGINITFSYSEKLLHARGTKLHLEKIKFF 355

  Fly   311 ----NWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTD---LAAWSS 368
                ..|:.:...||...|.     |.||.|       ..|:....|...:..|||   :..||.
plant   356 NSGELLLEKLLKVNFTGIAG-----QVQFGS-------GRNVIGCDYEIINVNKTDVHTVGFWSK 408

  Fly   369 VGEMRLLNETISPARRFFRIGTA-------ESIPWSYLRREEGTGELIRDRSGLPI--------- 417
            .|..    ..::|..|..:..|:       ..|.|....||:..|.:|.| |..|:
plant   409 NGGF----SVVAPKTRHSQKKTSFVSDEKLGDITWPGGGREKPRGWVIAD-SADPLKIVVPRRVS 468

  Fly   418 --------------WEGYCIDFIIRLSQKLNFEFEIV---------APEVGHMGELNELGEWDGV 459
                          .:|:|||..|...:.:.:....:         :|...|:.::...|.:|..
plant   469 FVEFVTEEKNSSHRIQGFCIDVFIEALKFVPYSVPYIFEPFGNGHSSPNYNHLIQMVTDGVYDAA 533

  Fly   460 VGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWL 523
            |||:.            :...|.:::||..| |..||:.:.|  |.. ..:.:.|:......:|.
plant   534 VGDIA------------IVPSRSKLVDFSQP-YASTGLVVVI--PANDDNATWIFLRPFTSRLWC 583

  Fly   524 SIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYACREFTLRESF---------WFALTSFTPQGG 579
            .::.:.:..|::||.:                    |..:.|.|         ...|.||:....
plant   584 VVLVSFLVIAVVIWIL--------------------EHRINEDFRGPPRRQLSTMLLFSFSTLFK 628

  Fly   580 GEAPKAISG-RMLVAAYWLFVVLML-ATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKD 642
            ......||. ..||...|||::::| |::||||.:.|||:::.:.:..::.| |.|.:.......
plant   629 RNQEDTISNLARLVMIVWLFLLMVLTASYTANLTSILTVQQLPSAITGIDSL-RASEVPIGYQAG 692

  Fly   643 SDTHQYFV-NMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKE 706
            :.|.:|.. ::..|...|      :.|:::::::|             .:.|...:...||
plant   693 TFTLEYLTYSLGMARSRL------VPLDSTEEYEK-------------ALKLGPTNWGGVA---- 734

  Fly   707 GFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILEL 771
                         |.:.:...|:..:........|||.|..:.:..|.::.|.|..::|.|||:|
plant   735 -------------AIVDELPYIELFLAERTGFKIVGEPFMHRGWGFAFKRDSPLAIDMSTAILKL 786

  Fly   772 QKDRFFEELKAKY-----------WNQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTL 825
            .:.|..:|::.|:           ||..  ||        .:.|:|..|:::..:...|.|.:..
plant   787 SETRKLQEIRKKWLCKTNCAGKSNWNPE--PN--------QLHLKSFKGLYLVCIAITVSAFLVF 841

  Fly   826 GMEVLYYKKKQNALEITQVRP 846
            .:.::....:...:|.|...|
plant   842 VLRMIRQFVRYRRMERTSSMP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	88/465 (19%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	62/320 (19%)
GLR5	NP_565744.1	PBP1_GABAb_receptor	32..416	CDD:107361	80/400 (20%)
		ANF_receptor	46..396	CDD:279440	74/376 (20%)
		GluR_Plant	458..800	CDD:270404	78/413 (19%)
		Lig_chan	581..832	CDD:278489	62/317 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910