DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and GLR2.7

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_180476.3	Gene:	GLR2.7 / 817460	AraportID:	AT2G29120	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	490	Identity:	103/490 - (21%)
Similarity:	199/490 - (40%)	Gaps:	101/490 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 LLNETISPARRFFRIGTAESIP--WSYLRREEGTGELIRDRSGLPIWE----------------- 419
            :|.|.:.|.   ...|.::.:|  |..    ...|:::  |.|:|:.:
plant   432 VLGERLGPV---IWPGKSKDVPKGWQI----PTNGKML--RVGIPVKKGFLEFVDAKIDPISNAM 487

  Fly   420 ---GYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSER 481
               ||||:....:.:||.:.   |.|:  ::..|:....:|.:|..:..|..|..:..:.:.:.|
plant   488 TPTGYCIEIFEAVLKKLPYS---VIPK--YIAFLSPDENYDEMVYQVYTGAYDAVVGDVTIVANR 547

  Fly   482 EEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPY 545
            ...:||..||.| :|:|:.:  |:: ..:.:.|:....|::|::.....|....::|.::    :
plant   548 SLYVDFTLPYTE-SGVSMMV--PLKDNKNTWVFLRPWSLDLWVTTACFFVFIGFIVWILE----H 605

  Fly   546 SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISG-RMLVAAYWLFVVLML-ATFTA 608
            ....:.:..|:    ..:..|||||   |:........|.:|. ...|...|.||||:| .::||
plant   606 RVNTDFRGPPH----HQIGTSFWFA---FSTMNFAHREKVVSNLARFVVLVWCFVVLVLIQSYTA 663

  Fly   609 NLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKD 673
            ||.:|.||:.:|..|.:.:.|.:.::                |:.:...|..|     .|..|:.
plant   664 NLTSFFTVKLLQPTVTNWKDLIKFNK----------------NIGYQRGTFVR-----ELLKSQG 707

  Fly   674 FKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCN- 737
            |.:.::      :.:|          ...:..|.|:|.....:.|     :.|.||..:::|.:
plant   708 FDESQL------KPFG----------SAVECDELFSNGTITASFD-----EVAYIKVILSQNSSK 751

  Fly   738 LTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCP---LSEDQ 799
            .|.|...|....:.....:.|.|.|::|.|||.:.:....:.::.|::.:.|  |||   .|...
plant   752 YTMVEPSFKTAGFGFVFPKKSPLTDDVSRAILNVTQGEEMQHIENKWFKKPN--NCPDLNTSLSS 814

  Fly   800 EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKK 834
            ..::|.|..|:|:.......||::......||..|
plant   815 NHLSLSSFWGLFLIAGIASFLALLIFVANFLYEHK 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	86/428 (20%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	64/303 (21%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor	40..421	CDD:107361
		ANF_receptor	54..405	CDD:279440
		GluR_Plant	460..799	CDD:270404	82/401 (20%)
		Lig_chan	584..832	CDD:278489	64/302 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910