DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GLR2.9

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001325277.1	Gene:	GLR2.9 / 817458	AraportID:	AT2G29100	Length:	942	Species:	Arabidopsis thaliana

Alignment Length:	1018	Identity:	203/1018 - (19%)
Similarity:	351/1018 - (34%)	Gaps:	302/1018 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TDIAMVLKELDA------LRLDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGAS-AVIDLTYSHW 93
            |.|.|.:.:..|      .||.:.|.|:      .||            ||.|| |.:||
plant    50 TSIKMAVSDFYADHPNYLTRLTLHVRDS------MED------------TVQASAAALDL----- 91

  Fly    94 EEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRT 158
                       |...::..|:.|...|..||| .|.||...:..:........:..:...|..|.
plant    92 -----------IKTEQVSAIIGPINSMQADFM-IKLANKTQVPTITFSATSPLLTSIKSPYFVRA 144

  Fly   159 LIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKA-------------DLFQR 210
            .|.|:||........:..|..|....|:........|..:|:.:|..             |..|:
plant   145 TIDDSSQVRAIASIFKFFRWRRVVAIYVDNEFGEGFMPFLFDALQDVEVKRSVIPPEAIDDEIQK 209

  Fly   211 PLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPD----LYCGSGFT-----MQRAM 266
            .|.   ..::.:.|||....::.|..|..    .|.|.:.|.:    ....:|.|     :....
plant   210 ELR---KLMERQARVFVVHMESSLALRVF----QIARDIGMMEEGYVWLMTNGMTHMMRHINNGR 267

  Fly   267 LLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSD-------------PLEKDDYNWLDMVHW 318
            .||.:..::......|              .|.|:.|             |..:||.|...:..:
plant   268 SLNTIEGVLGVRSHVP--------------KSKELGDFRLRWKRTFEKENPSMRDDLNVFALWAY 318

  Fly   319 SNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYY---SSEHEAKTDLA-------------AWS 367
            .:..|.|..:.               ..|..:.:|   |:..:.:|||.             |:|
plant   319 DSITALAKAVE---------------KANTKSLWYDNGSTLSKNRTDLGNVGVSLYGPSLQKAFS 368

  Fly   368 SV------GEMRLLNETI-SPARRFFR-IGTAESIPWSYLRRE------------------EGTG 406
            .|      ||.:|::..: ||...... :|..|.|...:..|:                  .|..
plant   369 EVRFNGLAGEFKLIDGQLQSPKFEIINFVGNEERIIGFWTPRDGLMDATSSNKKTLGPVIWPGKS 433

  Fly   407 ELI---------RDRSGLPIWEGYCIDFI-IRLSQKLNFE---------FE--------IVAPEV 444
            :::         :.|.|:|:.:|: .||: :.::...|.:         ||        :|.||.
plant   434 KIVPKGWEIPGKKLRVGVPMKKGF-FDFVKVTINPITNKKTPTGYAIEIFEAALKELPYLVIPEY 497

  Fly   445 GHMGELNELGE---------WDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIA 500
            ......|....         ||.||||:.            :.:.|....||..|:.| :|:|:.
plant   498 VSFESPNNYNNLVYQVYDKTWDAVVGDIT------------ITANRSLYADFTLPFTE-SGVSMM 549

  Fly   501 IRKPVR---RTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYACREFT 562
            :  |||   ....:.|:....||:|::.....|....::|..:.......|...|        :.
plant   550 V--PVRDNENKDTWVFLEPWSLELWVTTGCFFVFIGFVVWLFEHRVNTDFRGPPQ--------YQ 604

  Fly   563 LRESFWFALTSFTPQGGGEAPKAISG-RMLVAAYWLFVVLMLA-TFTANLAAFLTVERMQTPVQS 625
            :..|.||   ||:..........:|. ...|...|.||||:|. ::||:|.:||||:.:|..|.:
plant   605 IGTSLWF---SFSTMVFAHRENVVSNLARFVVVVWCFVVLVLTQSYTASLTSFLTVQSLQPTVTN 666

  Fly   626 LEQLAR-QSRINY---TVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKE 686
            :..|.: :..:.|   ..|||     ..:.:.|.||.|      ...:::||
plant   667 VNDLIKNRDCVGYQGGAFVKD-----ILLGLGFHEDQL------KPFDSAKD------------- 707

  Fly   687 QYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCN-LTEVGEVFAEQPY 750
              ...||:...|:.:|                 |...:.|.:|..::::|: ...|...|....:
plant   708 --ADDLLSKGKSKGIA-----------------AAFDEVAYLKAILSQSCSKYVMVEPTFKTGGF 753

  Fly   751 AVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCP-----LSEDQEGITLESLGGV 810
            ..|..:.|.|..|.|.|||.|.::...::::.:::.:.|  :||     ||.::  :.|.|..|:
plant   754 GFAFPKNSPLTGEFSRAILNLTQNNVTQQIEDRWFPKKN--DCPDPMTALSSNR--LNLSSFLGL 814

  Fly   811 FI----ATLFGLVLAMM--------TLG--MEVLYYKKKQNALEITQVRPVNDSS--GSGGNSST 859
            |:    |..|.|::.:.        |||  .|...::|.:...:|...:.:|..:  .|..::.:
plant   815 FLIAGTAISFSLLVFVALFLYEHRHTLGDDSEDSLWRKLKFLFKIFDEKDMNSHTFKNSAIHNIS 879

  Fly   860 AP-----PTATSTTKQAW-HIPVLEAEEKPAKVSPPPSFETAT 896
            :|     |:.::.....| ..|....|.:..:||..||.|..|
plant   880 SPMTHKTPSPSTVQITPWPQSPSQNREFELRRVSFSPSEERFT 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	94/467 (20%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	69/313 (22%)
GLR2.9	NP_001325277.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910