DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GLR2.2

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	573	Identity:	126/573 - (21%)
Similarity:	221/573 - (38%)	Gaps:	143/573 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 LDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNI------SAGYYSS--------EHEAKT-- 361
            |..|....|...|.....:..|.|   |.:...||:      |.|:::.        :.|.::
plant   359 LQTVSTVQFKGLAGDFHFVSGQLQ---PSVFEIVNMIGTGERSIGFWTEGNGLVKKLDQEPRSIG 420

  Fly   362 DLAAWSSVGEMRLLNETISPARRFFRIGTAESIP--WSY------LR----REEGTGELI---RD 411
            .|:.|..     .|...|.|       |.|.|:|  |..      ||    :..|..:|:   ||
plant   421 TLSTWPD-----HLKHIIWP-------GEAVSVPKGWEIPTNGKKLRIGVPKRIGFTDLVKVTRD 473

  Fly   412 R-SGLPIWEGYCIDFIIRLSQKLNFE-----FEIVAPEVGHMGELNE------LGEWDGVVGDLV 464
            . :...:.:|:||||...:.|.:.::     |....|.....|..|:      ||::|.||||..
plant   474 PITNSTVVKGFCIDFFEAVIQAMPYDVSYEFFPFEKPNGEPAGNHNDLVHQVYLGQFDAVVGDTT 538

  Fly   465 RGETDFAIAALKMYSEREEVIDFLPPYYEQ-TGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAA 528
                        :.:.|...:||..|:.:. .|:.:.::..|:|.. |.|:..|.:|:||:.:..
plant   539 ------------ILANRSSFVDFTLPFMKSGVGLIVPLKDEVKRDK-FSFLKPLSIELWLTTLVF 590

  Fly   529 LVGTAIMIWFMDK--YSPYSSRNNRQAYPYACREFTLRESFWFALTS--FTPQGGGEAPKAISGR 589
            .....|.:|.::.  .|.:....|.||          ...||||.::  |.|:   |...:...|
plant   591 FFLVGISVWTLEHRVNSDFRGPANYQA----------STIFWFAFSTMVFAPR---ERVLSFGAR 642

  Fly   590 MLVAAYWLFVVLMLA-TFTANLAAFLTVERMQTPVQSLEQLA-RQSRINYTVVKDSDTHQYFVNM 652
            .||.. |.||:|:|. ::||:||:.||.:::...:.|:..|. |...:.|
plant   643 SLVVT-WYFVLLVLTQSYTASLASLLTSQQLNPTITSMSSLLHRGETVGY--------------- 691

  Fly   653 KFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFAN--VDAHE 715
               :.|.:.:.|   ||.: .|.:..:..:...|:...:|            |:|..|  |.|
plant   692 ---QRTSFILGK---LNET-GFPQSSLVPFDTAEECDELL------------KKGPKNGGVAA-- 735

  Fly   716 NADYAFIHDSAEIKYEITRNCNLTE-VGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEE 779
                ||: .:..::..:.:.||..: |.|.|....:......||.|..::|.|||::.:.....|
plant   736 ----AFL-GTPYVRLFLGQYCNTYKMVEEPFNVDGFGFVFPIGSPLVADVSRAILKVAESPKAVE 795

  Fly   780 LKAKYWNQSNLPNC--PLSEDQEGITLESL----GGVFIATLFGLVLAMMTLG 826
            |: ..|.:....:|  |::......|:.::    |..:...|...|:.::.||
plant   796 LE-HAWFKKKEQSCPDPVTNPDSNPTVTAIQLGVGSFWFLFLVVFVVCVLALG 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	100/439 (23%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	68/312 (22%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	11/55 (20%)
		ANF_receptor	47..392	CDD:279440	9/35 (26%)
		HisJ	438..>587	CDD:223904	40/161 (25%)
		GluR_Plant	452..801	CDD:270404	95/417 (23%)
		Lig_chan	582..819	CDD:278489	65/292 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910