DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and GLR2.3

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001325281.1	Gene:	GLR2.3 / 817007	AraportID:	AT2G24710	Length:	919	Species:	Arabidopsis thaliana

Alignment Length:	516	Identity:	115/516 - (22%)
Similarity:	202/516 - (39%)	Gaps:	132/516 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 GTAESIP--WSY------LR----REEGTGELI---RDRSGLPIWE-----GYCIDF---IIR-L 429
            |.|:|:|  |..      ||    :..|..:|:   ||    ||..     |:||||   :|| |
plant   460 GEADSVPKGWQIPTKGKKLRIGVPKRTGYTDLVKVTRD----PITNSTVVTGFCIDFFEAVIREL 520

  Fly   430 SQKLNFEF-EIVAPEVGHMGELNE------LGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDF 487
            ...:::|| ....|:....|..|:      ||.:|.||||..            :...|...:||
plant   521 PYDVSYEFIPFEKPDGKTAGNYNDLVYQVYLGRYDAVVGDTT------------ILVNRSSYVDF 573

  Fly   488 LPPYYEQ-TGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMD-KYSPYSSRNN 550
            ..|:.:. .|:.:.:..||:|..:. ||..|..::||:...:.......:|.:: |.:|..|...
plant   574 TFPFIKSGVGLIVEMTDPVKRDYIL-FMKPLSWKLWLTSFISFFLVGCTVWVLEYKRNPDFSGPP 637

  Fly   551 RQAYPYACREFTLRESFWFALTS--FTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAF 613
            |......|         |||.::  |.|:   |...:...|.||.|::..|:::..::||:||:.
plant   638 RFQASTIC---------WFAFSTMVFAPR---ERVFSFWARALVIAWYFLVLVLTQSYTASLASL 690

  Fly   614 LTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQY----FVNMKFAEDTLYRMWKELALNASKDF 674
            ||.:::...:.|:..|          ::..:|..|    |:..|..|               :.|
plant   691 LTSQKLNPTITSMSSL----------LEKGETVGYQRTSFILGKLKE---------------RGF 730

  Fly   675 KKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKY---EITRNC 736
            .:..:..:...|:...:|    |..|......|            ||:    ||.|   .:.:.|
plant   731 PQSSLVPFDTAEECDELL----SKGPKKGGVSG------------AFL----EIPYLRLFLGQFC 775

  Fly   737 NLTE-VGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCP------ 794
            |..: |.|.|....:......||.|..::|.|||::.:.....||: :.|.:....:||
plant   776 NTYKMVEEPFNVDGFGFVFPIGSPLVADVSRAILKVAESPKAMELE-RAWFKKKEQSCPDPITNP 839

  Fly   795 ---LSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYY--KKKQNALEITQVRPVNDS 850
               .|.....:.::|...:|:..   |::.:|.||.....:  |.:.:.|:..::.|.:.|
plant   840 DPNPSFTSRQLDIDSFLFLFVGV---LLVCVMALGNFTYCFLAKDQVSYLDKVEMSPCSSS 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	101/439 (23%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	63/317 (20%)
GLR2.3	NP_001325281.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910