DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GLR2

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	984	Identity:	199/984 - (20%)
Similarity:	368/984 - (37%)	Gaps:	276/984 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVLLLALRFAGSEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTTLT--------LT 62
            |.::.||:|..::|:.|   |.| |.:.....::.:..||....|.....|.||:        .|
plant    86 LSIMGALQFMETDVVAI---IGP-QTSIMAHVLSHLANELTVPMLSFTALDPTLSPLQFPFFVQT 146

  Fly    63 RSEDGLDMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQ 127
            ...|...|:...|:::..|.|.|:.| |:..:...|.|.:|                  ||.:.:
plant   147 APSDLFLMRAIAEMITYYGWSDVVAL-YNDDDNSRNGVTAL------------------GDELEE 192

  Fly   128 KRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLE--RIRSLRPAPTYIALFA 190
            :|..                    :.|. ..|.:|...|.|.:...|  :||.:......:..|.
plant   193 RRCK--------------------ISYK-AVLPLDVVITSPVEIIEELIKIRGMESRVIVVNTFP 236

  Fly   191 RAAAMNGIFEKVQKADLFQRPLEW-----------HFVFLDT-----------------RDRVFK 227
            ....|  ||::.::..:.::...|           ..:.|||                 :.|.|.
plant   237 NTGKM--IFKEAERLGMMEKGYVWIATTWLSSVLDSNLPLDTKLVNGVLTLRLHTPDSRKKRDFA 299

  Fly   228 YRRQAELCTRFTLNPRA-----------ICRSMPMPDLYCGSGFTMQRAMLLNVLR-SLINAAQV 280
            .|.:.:|....|:....           |.|::... |..|...:......|..|: ..:|.:.:
plant   300 ARWKNKLSNNKTIGLNVYGLYAYDTVWIIARAVKTL-LEAGGNLSFSNDAKLGSLKGEALNLSAL 363

  Fly   281 S---PGYPLAIYQDCNATASSSEVSDPLE--------KDDYNWLDMV--------HWSNF--LAY 324
            |   .|..|.   |.......|.::.|::        :..|:.:::|        :|||:  |:.
plant   364 SRFDQGSQLL---DYIVHTKMSGLTGPVQFHPDRSMLQPSYDIINLVDDRVHQIGYWSNYSGLSI 425

  Fly   325 APPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFF--- 386
            .||     :.|.|..|      |.|:   |::|   .:...|..       ..:::|....|
plant   426 VPP-----ESFYSKPP------NRSS---SNQH---LNSVTWPG-------GTSVTPRGWIFRNN 466

  Fly   387 ----RIGTAESIPW-SYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGH 446
                |||..:...: .::.|..|:...:         :|||||......:.|::.   |..|...
plant   467 GRRLRIGVPDRASFKDFVSRVNGSSNKV---------QGYCIDVFEAAVKLLSYP---VPHEFIF 519

  Fly   447 MGE------LNEL-------GEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGIS 498
            .|:      .|||       .::|.||||:.            :.::|..::||..||.|...:.
plant   520 FGDGLTNPNYNELVNKVTTGVDFDAVVGDIA------------IVTKRTRIVDFTQPYIESGLVV 572

  Fly   499 IAIRKPVRR--TSLFKFMTVLRLEVWLSIVAA---LVGTAIMIWFMDKYSPYSSRNNRQAYPYAC 558
            :|   ||.|  .:.:.|:....|.:| ::.|:   :||.|  ||.::     ...|:....|...
plant   573 VA---PVTRLNENPWAFLRPFTLPMW-AVTASFFVIVGAA--IWILE-----HRINDEFRGPPRR 626

  Fly   559 REFTLRESFWFALTS--FTPQGGGEAPKAISGRMLVAAYWLFVVLML-ATFTANLAAFLTVERMQ 620
            :..|:   .||..::  |:.:   |...:..||| |...||||||:: :::||:|.:.|||:::.
plant   627 QIITI---LWFTFSTMFFSHR---ETTVSTLGRM-VLLIWLFVVLIITSSYTASLTSILTVQQLN 684

  Fly   621 TPVQSLEQL-ARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPI 684
            :|::.::.| :...||.:.|            ..|||:   .|..||.:.:|:
plant   685 SPIKGVDTLISSTGRIGFQV------------GSFAEN---YMTDELNIASSR------------ 722

  Fly   685 KEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAE-IKYEITRNCNLTEVGEVFAEQ 748
                         ..|:|..:| :||  |.:|...|.|.|... |...::..|.....|:.|...
plant   723 -------------LVPLASPEE-YAN--ALQNGTVAAIVDERPYIDLFLSDYCKFAIRGQEFTRC 771

  Fly   749 PYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNL--PNCPLSEDQEGITLESLGGVF 811
            .:..|..:.|.|..::|.|||.|.:....:::..::.::||.  |:...|.|.|.:.:.|..|:|
plant   772 GWGFAFPRDSPLAVDMSTAILGLSETGELQKIHDRWLSKSNCSSPHGSQSGDSEQLNVHSFWGMF 836

  Fly   812 IATLFGLVLAMMTLGMEVLYYKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHIPV 876
            :......::|:.     :.::|..::..:.|....|.::..|        |.::..||....:..
plant   837 LVVGIACLVALF-----IHFFKIIRDFCKDTPEVVVEEAIPS--------PKSSRLTKLQTFLAF 888

  Fly   877 LEAEEKPAK 885
            ::.:|:..|
plant   889 VDEKEEETK 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	99/433 (23%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	73/307 (24%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	69/387 (18%)
		GluR_Plant	468..808	CDD:270404	98/424 (23%)
		Lig_chan	594..843	CDD:306551	73/306 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910