DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and grik5

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	956	Identity:	237/956 - (24%)
Similarity:	395/956 - (41%)	Gaps:	211/956 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELPLLVLLLALRFAGSEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTT-------- 58
            |||.|:|.:..||     |.:|....|..... .|.:      |.::|:...:||::
Zfish     3 ELPALLLSIYFRF-----LLVTVVTMPPSSLS-QTPV------LSSVRMAAILDDSSVCGRGERL 55

  Fly    59 -LTLTRSE---------------DGLDMQR---------FCEIL-----STVG--ASAVIDLTYS 91
             |.|.|..               |..::|:         .|:||     |.:|  :|.......|
Zfish    56 ALALARENINSVMENPARARVEVDIFELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVS 120

  Fly    92 HWEEGYNLVRSLGIGYVRLERIMRPFL------------DM---FGDFMRQKRANNVAMVFMNAR 141
            | ..|...:..:.||.....|:  |:|            |:   .|..:|.....:.::|...|.
Zfish   121 H-ICGEKEIPHVKIGPEETPRL--PYLRFASVTLYPSNEDLSLAIGSILRSFSYPSASLVCAKAE 182

  Fly   142 DAV---EAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQ 203
            ..:   |.:::.|:.....::.|.....|| ...|:.||..:.|.  |.:.|.|:....|.:|..
Zfish   183 CLLRLEELIRRFLISRETLSIRMLDDNLDP-TPLLKEIRDDKIAT--IIIDANASISYLILKKAS 244

  Fly   204 KADL---FQR--------PLEWHFVFLDTRDRVFKYRR-------QAELCTRFTLNPRAICRSMP 250
            :..:   |.:        ||.|....:|.:..:..:..       ..|......|:.|..|...|
Zfish   245 ELGMTSAFYKYILTTMDFPLLWLDDIVDEQSNIVGFSMFNTTHPFYLEFIRSLNLSWREGCDINP 309

  Fly   251 MPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVS-DPLEKDD----- 309
            .|      |..:..|:|.:.:..:::|.           |:.|   .|.|:. .||....
Zfish   310 YP------GPALSSALLFDAVHVVVSAV-----------QELN---RSQEIGVKPLSCTSPQIWQ 354

  Fly   310 -----YNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSV 369
                 .|:|.||.:.....        :.:|.|......:.::|...:.....|    :..|.|.
Zfish   355 HGTSLMNYLRMVEYDGLTG--------RVEFNSKGQRTNYTLHILEKHRGGHKE----IGIWYSN 407

  Fly   370 GEMRLLNET-----ISP--ARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFII 427
            ..: |:|.|     :|.  |.:...|.|....|  |:.|:....|.    .|...:||:|:|.:.
Zfish   408 NTL-LMNSTSLDINVSETLANKSLIITTILENP--YVMRKINYQEF----EGNEQYEGFCVDMLR 465

  Fly   428 RLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYY 492
            .||..|.|.:.|...:.|..|.....|.|.|:||:|:..:.|.|:||..:.||||:||||..|:.
Zfish   466 ELSDILKFTYRIKLVDDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITSEREKVIDFSKPFM 530

  Fly   493 EQTGISIAIRKPV-RRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPY 556
             ..||||..|..: |:...|.|:......|||.::.|.:..:.:::...:.|||...|     |:
Zfish   531 -TLGISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLSARLSPYEWYN-----PH 589

  Fly   557 AC---------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAA 612
            .|         .::||..|.||.:..|..||....|:|:|.|.:...:|.|.:::::::||||||
Zfish   590 PCLRERRDLLENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAA 654

  Fly   613 FLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKF 677
            ||||:||:.|::|.:.||.|:.|.|..:....|..:|:|.::  .|..|||..:
Zfish   655 FLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRY--QTYQRMWNYM----------- 706

  Fly   678 RIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLT 739
                              .|.||   |...:||.|.|   .|:.|||:.:|...:|..:.|||||
Zfish   707 ------------------YSKQPSVFVKSTEEGIARV---VNSKYAFLLESTMNEYHRSLNCNLT 750

  Fly   740 EVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQ--EGI 802
            ::|.:...:.|.:.:..||...||||.|:|:||::...|.||.::|...   .||..||.  :|:
Zfish   751 QIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKRRWWEGG---KCPKEEDHRAKGL 812

  Fly   803 TLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQVRPVN 848
            .:|::||:|:..:.||::|:....||.::..::  :.|..:|||::
Zfish   813 GMENIGGIFVVLICGLIIAVFVAVMEFVWSTRR--SAETDEVRPLS 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	129/415 (31%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	94/311 (30%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	72/412 (17%)
		ANF_receptor	55..392	CDD:279440	66/370 (18%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	15/91 (16%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	129/415 (31%)
		Lig_chan	558..828	CDD:278489	94/311 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910