Protein Alignment Ir8a and gria1a

DIOPT Version :9

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_991161.1
• Gene: gria1a / 798689
• ZFINID: ZDB-GENE-020125-1
• Length: 914
• Species: Danio rerio
• Alignment Length: 613
• Identity: 169/613 - (27%)
• Similarity: 284/613 - (46%)
• Gaps: 135/613 - (22%)

  Fly   326 PPLP-----HIQDQFQS-PVPGLT-------------FAVNI---------SAGYYSSEHEAKTD 362
            ||.|     .||...|. .:.|||             :::::         ..||: :|.|....
Zfish   325 PPAPWGQGIDIQRALQQVRIEGLTGHIQFNEKGRRTNYSISVMELRPTGPKKVGYW-NEDEKFVS 388

  Fly   363 LAAWSSVGEMRLLNETISPARRFFRIGTAESIPWSYLRR--EEGTGELIRDRSGLPIWEGYCIDF 425
            .||:     |...|||.....|.:.:.|....|:..|::  |..||   .|:     :||||::.
Zfish   389 TAAY-----MPGSNETYGLQNRTYIVTTILESPYVMLKKNHEHFTG---NDK-----YEGYCVEL 440

  Fly   426 IIRLSQKLNFEF--EIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDF 487
            ...:::.:.:.:  :|||.  |..|..: |...|:|:||:||.|:.|.|:|.|.:...|||||||
Zfish   441 AAEIAKHVGYHYILKIVAD--GKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDF 503

  Fly   488 LPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPY------ 545
            ..|:. ..||||.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::::.:.::|||
Zfish   504 SKPFM-SLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADD 567

  Fly   546 ---------------------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGR 589
                                 :.:|..|.......||.:..|.||:|.:|..||...:|:::|||
Zfish   568 CEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGR 632

  Fly   590 MLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKF 654
            ::...:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..:....|.::|...|.
Zfish   633 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKI 697

  Fly   655 AEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHEN 716
            |.                 |:|  :|.|            :.|:.|   |....||...| ....
Zfish   698 AV-----------------FEK--MWSY------------MKSADPSVFVKTTDEGVMRV-RKSK 730

  Fly   717 ADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEEL 780
            ..||::.:|...:| |..:.|:..:||.....:.|.:|..:||.|.:.::.|:|:|.:....::|
Zfish   731 GKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKL 795

  Fly   781 KAKYWNQSNLPNCPL----SEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE 840
            |.|:|....  .|..    |:|: ..::|.::.|||...:.||.|||:...:| ..||.:..:..
Zfish   796 KNKWWYDKG--ECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVE-FCYKSRTESRR 857

  Fly   841 ITQVRPVNDS-----------SGSGGNS 857
            :.|  .:||:           :||||.:
Zfish   858 MKQ--SINDAMHCSTLTRMSGNGSGGEN 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	127/439 (29%)
		Lig_chan	520..818	CDD:278489	88/333 (26%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	13/62 (21%)
		ANF_receptor	36..369	CDD:279440	9/43 (21%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	128/446 (29%)
		Lig_chan	536..836	CDD:278489	88/333 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910