Protein Alignment Ir8a and grin3ba

DIOPT Version :9

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_021323058.1
• Gene: grin3ba / 566411
• ZFINID: ZDB-GENE-070912-354
• Length: 1118
• Species: Danio rerio
• Alignment Length: 1003
• Identity: 206/1003 - (20%)
• Similarity: 348/1003 - (34%)
• Gaps: 326/1003 - (32%)

  Fly    58 TLTLTRSEDGLDMQRFCEILS-------TVGASAVI---------------------DLTYSHWE 94
            ||.|:|.|:.:...:..|:||       :..||:|:                     .|...||.
Zfish   218 TLNLSRLEENISEDKVMELLSQLLSRTPSAPASSVVLFGSDPECTATVLHCAHQLSGTLPPMHWI 282

  Fly    95 EGYNL----VRSLG-----IGYVRLER-----IMRPFLDMFGDFMRQKRANNVAMVFMNARDAVE 145
            .||.|    :.|:|     :.|..:.|     .:|..|.:.|      ||...|.:   .|..:.
Zfish   283 MGYPLSLDSLHSIGSPLGLMAYGEVNRKPLNFYIRDTLQLIG------RAVYAATM---VRPDLA 338

  Fly   146 AMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQR 210
            .:|.|:..:           ..|.:|      .|..:..|:|.|....:..|:...|:....|.|
Zfish   339 LIQNMVNCF-----------DKPNKH------ELPSSGQYLARFLSNTSFTGLTGPVRVERSFSR 386

  Fly   211 PLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLI 275
            .|                                                |.||..:.::.|
Zfish   387 VL------------------------------------------------TSQRFHIWSLQR--- 400

  Fly   276 NAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVP 340
                                       |||.:.  :|:.:..|.:        ..::.:.|...|
Zfish   401 ---------------------------DPLGQP--SWVTVASWQS--------GRLELEEQGLWP 428

  Fly   341 GLTFAVNISAGYYSSEHEAKTDL-----AAWSS---VGEMRLLNETISPARRFFRIGTAESIPWS 397
            |:|            :|:.:...     ..|.:   |...||            |:.|....|:.
Zfish   429 GVT------------QHQREDGPGIRLGGRWQAGLPVAGSRL------------RVVTLVEHPFV 469

  Fly   398 YLRR--EEG---TGELIRD--------------------RSGLP-----IWEGYCIDFIIRLSQK 432
            :.|.  |||   .|:|..|                    .|.||     ...|||||.:.:|::.
Zfish   470 FTREVDEEGQCPAGQLCLDPQTNNSEVLNQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAED 534

  Fly   433 LNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGI 497
            ::|||::.....|..|.... |.|.|:||||:.|..|.|:.:..:.|.|..||||..|:: .|.:
Zfish   535 MHFEFDLYIVGDGKYGAWKG-GRWSGLVGDLLSGVADMAVTSFSINSARSRVIDFTSPFF-STSL 597

  Fly   498 SIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYS----SRNNRQAYPYAC 558
            .|.:|.......:..||..|...:|:.|..||..||:.|...:..||:.    .||..:.:.|:
Zfish   598 GILVRSKDTAAPIGAFMWPLHWSMWVGIFVALHITALFITLYEWNSPFGMTPHGRNRIRVFSYS- 661

  Fly   559 REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPV 623
            ....|..:..|..|.     ..:.||..:||.|:..:.:|.:|:|:::||||||.:..|:
Zfish   662 SALNLCYAILFGRTV-----ASKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEK----- 716

  Fly   624 QSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQY 688
             :.|:::.        :.|...|...:..:|.         .:..::::|:.|   ..:|...:|
Zfish   717 -TFEEVSG--------IHDVKLHHPSLGFRFG---------TVRESSAEDYVK---KSFPEMHEY 760

  Fly   689 GHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEIT--RNCNLTEVGEVFAEQPYA 751
            ........:...|:..|.....:|       |||.|.|.:.||::  .:|.|..||:.||.:.|.
Zfish   761 MRRFNKPTTPDGVSTLKTDPPQLD-------AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYG 818

  Fly   752 VAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGIT------LESLGGV 810
            :.:.|.|.|...:|..:...:.|.:.:.|..|::..     .|..:....:|      ::...|:
Zfish   819 IGLPQNSPLTRNVSEYVSRYKSDGYMDMLHDKWYKV-----VPCGKRVFAVTETLQMGIQHFSGL 878

  Fly   811 FIATLFGLVLAMMTLGME------VLYYKKKQNA----LEITQV--RPVN----DSSGSGGN--- 856
            |:....|:..|::||..|      :|.:.:.|..    |..:|.  |.:|    |...|...
Zfish   879 FVLLCVGVAGALLTLLGEHAFFRFILPHLRHQQRFKYWLHTSQKIHRAINMGCDDERKSEAESSD 943

  Fly   857 ------------------SSTAPP--TATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKK 901
                              ||::||  ::||||...|:...::|..:..:.:....|...|....:
Zfish   944 RCPTLCLSENCNLHRLPPSSSSPPSTSSTSTTTTKWNNQSVKAGREAKEQNKRVHFNLETLNSYQ 1008

  Fly   902 LPARITLGDGKFKPRHGL-YARRNLGAS 928
            |.|          |.||. ..||.|..|
Zfish  1009 LQA----------PPHGAERGRRGLVGS 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	109/438 (25%)
		Lig_chan	520..818	CDD:278489	66/309 (21%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	51/323 (16%)
		PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	111/447 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810